nHA/Mg/壳聚糖膜复合材料的制备及耐腐蚀性研究

›› 2015, Vol. 35 ›› Issue (6): 433-437.

nHA/Mg/壳聚糖膜复合材料的制备及耐腐蚀性研究

何畔,仲琦,卢建忠,车鸿泽,马宁

吉林大学口腔医院

收稿日期:2015-01-26 修回日期:2015-03-23 出版日期:2015-06-28 发布日期:2015-07-01
通讯作者: 马宁 E-mail:maningbsh76@sina.com
基金资助:
促进颌骨缺损修复的PLGA涂层nHA/Mg复合材料;PLGA涂层nHA /Mg复合材料的制备及生物相容性的研究

Preparation and properties of nHA/Mg/chitosan coating composite materials

Received:2015-01-26 Revised:2015-03-23 Online:2015-06-28 Published:2015-07-01

摘要/Abstract

摘要： [摘要] 目的通过对nHA/Mg/壳聚糖膜的合成及检测，探索制备一种新型优质可降解支架材料。方法采用粉末冶金法制备了nHA/Mg复合材料，选用碳酸氢铵作为造孔剂，浸泡法在nHA/Mg复合材料表面制备壳聚糖膜，SEM观察复合材料表面、截面形态结构及在模拟体液浸泡腐蚀后表面形态的变化。结果 nHA/Mg平均孔隙率达50%，孔径约50~120 μm，碳酸氢铵为合适的造孔剂，壳聚糖膜可显著改善材料降解的时间及pH值，减缓了镁合金的腐蚀速率。结论 nHA/Mg/壳聚糖膜复合材料是多孔隙结构、耐腐蚀性良好的可降解支架材料。

关键词: 支架材料, 镁, 羟基磷灰石, 壳聚糖膜

Abstract: Abstract: Objective By compounding and testing nHA/Mg/chitosan coating, to explore the preparation of a high-quality biodegradable scaffold materials. Methods The nHA/Mg composites were synthesized by powder metallurgy. With ammonium bicarbonate as pore-forming agent, chitosan coating was prepared by immersion method on the surface of nHA/Mg alloy. The composite surface, the morphological structure of cross section, and the surface morphology changed after being soaked in simulated body fluid corrosion were observed by SEM. Results The average porosity of nHA/Mg alloy was 50%, and the pore diameter was 50~120μm. Ammonium bicarbonate was the suitable pore-forming agent, and chitosan coating could significantly improve the material degradation time and PH value, slowing down the corrosion rate of the magnesium alloy. Conclusion The composite material nHA/Mg/chitosan coating was a biodegradable scaffold with porous structure and good corrosion resistance.

Key words: Scaffold materials, Magnesium, nano-hydroxyapatite, Chitosan coating

中图分类号:

R318.08

何畔仲琦卢建忠车鸿泽马宁. nHA/Mg/壳聚糖膜复合材料的制备及耐腐蚀性研究[J]. 口腔医学, 2015, 35(6): 433-437.

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