›› 2015, Vol. 35 ›› Issue (6): 456-460.

• 临床研究 • 上一篇    下一篇

戴用固定矫治器患者尿镍含量的变化研究

朱静涛,郭咏娟,刘奕   

  1. 中国医科大学附属口腔医院
  • 收稿日期:2014-10-22 修回日期:2014-12-01 出版日期:2015-06-28 发布日期:2015-07-01
  • 通讯作者: 刘奕 E-mail:liuyi256@126.com
  • 基金资助:
    辽宁省科学技术计划项目;辽宁省自然科学基金

Changes of urinary nickel contents of adolescents with orthodontic fixed appliances

  • Received:2014-10-22 Revised:2014-12-01 Online:2015-06-28 Published:2015-07-01

摘要: 目的 定量评估正畸治疗初期固定矫治器对青少年患者尿镍含量的影响,并进一步探讨其动态变化规律,观察其含量是否在正常范围内,从而判断其对人体健康是否有影响。方法 分别在治疗前(T0)和治疗后1个月、3个月、6个月(T1、T2、T3)共四个时间段收集正畸治疗且年龄范围在10-14岁之间的31名患者(男15名,女16名)的尿样,编号后密封、低温保存。采用石墨炉原子吸收光谱法测定尿样中镍元素的含量。结果 固定正畸矫治器可影响青少年患者的尿镍含量,且与矫治器戴用时间和性别相关。与T0期相比,T1、T2和T3期的尿镍含量显著增加(P<0.01)。男性平均尿镍浓度高于女性,但二者的平均动态变化曲线基本一致。结论 正畸治疗初期固定矫治器可显著影响青少年患者的尿镍含量,且与采矫治器戴用时间的长短和性别相关。正畸矫治器及其附件的含镍量不会威胁到人体健康,但为避免出现不良反应,建议使用无镍合金材料。

关键词: 固定矫治器, 尿镍浓度, 石墨炉原子吸收光谱法

Abstract: Objective The purpose of this study was to quantitatively evaluate urinary nickel levels, compare with normal physiological nickel index and summarize the dynamic metabolic regularity of systemic nickel for adolescents in the initial period of orthodontic fixed treatment. Methods The subjects were consisted of 15 boys and 16 girls (age range: 10-14 years). Urinary samples were collected before treatment (T0) and at three time points (1 month, 3 months, 6 months, respectively T1, T2, T3) after initial treatment, and stored in a low-temperature freezer until the atomic absorption spectrophotometry was carried on. Results The urinary nickel levels of adolescents could be affected significantly by orthodontic fixed appliances. Genders may be associated with different time points. Urinary nickel levels of T1, T2 and T3 were higher than T0. Though the levels of boys are higher that those of girls, the curve depicted of boys and girls might have a similar dynamic changing trend. Conclusion The urinary nickel levels of adolescents could be affected significantly by orthodontic fixed appliances, and may be associated with sampling time periods and genders, which materials without nickel was suggested for clinical treatment.

Key words: fixed appliances, Urinary Nickel Levels, Graphite Furnace Atomic absorption spectrophotometry

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