Abstract: Objective To evaluate the effect of arginine(Arg) combined with Bioglass(BAG) on the remineralization of early caries lesions in deciduous enamel . Methods Caries-like enamel lesions of were assigned to 5 experimental groups : (1) 6%BAG, (2) 6%BAG+1%Arg, (3) 6%BAG+2%Arg, (4) 6%BAG+4%Arg, (5) deionized water and transported to a 14 day's pH-cycline. Vickers hardness test evaluated the mechanical properties through enamel microhardness recovery ratio (% REMH). Surface morphologies along with Ca (Wt%)、P (Wt%),、and Ca/P atomic ratio were observed using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy. Results % REMH processed by each group were (54.49±2.44), (65.95±4.11), (67.00±2.03), (63.73±1.64b), (8.46±2.63c); a newly formed layer was found in all groups, among which the 2% and 4% arginine combined groups showed the flattest; the Ca(wt%)、P (wt%) and Ca/P ratio were significantly higher in combination groups than bioglass group, and 2% and 4% arginine combination groups showed the similar Ca/P to the normal enamel. Conclusion Arginine and bioactive glass have a synergistic effect on the remineralization of deciduous teeth, and the 2% arginine combined with 6% bioglass showed the best comprehensive ability.

Key words: arginine, bioglass, deciduous teeth, remineralization