Abstract: Bone morphogenetic protein 1 (BMP1) and mammalian tolloidlike 1(mTLL1), members of astacin family, are extracellular matrix metalloproteinases that are coexpressed in various tissues including teeth. BMP1 and mTLL1 are functionally redundant, playing an important role in cutting and activating extracellular matrix (ECM) proteins. They regulate ECM deposition by hydrolyzing and pruning precursors of various ECM proteins. Previous studies have shown that BMP1 and mTLL1 play an important role in tooth development through promoting the differentiation of odontoblasts and osteoblast, as well as maintaining the balance of collagen and noncollagen proteins in ECM. The research progress of BMP1 and mTLL1 in tooth development is reviewed in this paper.

Key words: bone morphogenetic protein 1, mammalian tolloid like 1, tooth development