组织蛋白酶K与口腔颌面部疾病

摘要/Abstract

摘要： 组织蛋白酶K（cathepsin K，CTSK）曾被认为是破骨细胞特异性的胶原酶，在骨吸收过程中发挥重要作用。但随着研究的深入，人们发现CTSK在更加广泛的细胞、组织及器官中均有表达，不仅参与机体正常生理活动的调节，还与多种疾病的发生发展密切相关。本文综述了CTSK在牙周炎、种植体周围炎、牙齿移动、口腔颌面部肿瘤、牙根吸收及根尖周病等口腔颌面部疾病中的研究进展。

关键词: 组织蛋白酶K, 致密性成骨不全, 牙周炎, 牙齿移动, 牙根吸收, 根尖周病

Abstract: 　Cathepsin K(CTSK) was once regarded as a collagenase specifically expressed by osteoclasts and played an important rolein bone resorption. However, more and more research found that CTSK was expressed in more extensive cells, tissues and organs. It may not only participate in regulating human physiological activity, but also be closely related to a variety of diseases. This paper reviewed the research progress on the role of CTSK in stomatognathic diseases includingperiodontitis, peri-implantitis, tooth movement, oral and maxillofacial tumor, root resorption and peri-apical disease.

Key words: Cathepsin K, Pycnodysostosis, Periodontitis, Tooth movement, Root resorption, Periapical diseases

中图分类号:

R393

移丽珍温宣薛洋. 组织蛋白酶K与口腔颌面部疾病[J]. , 2015, 35(10): 881-884.

参考文献

[1]Xue Y,Cai T,Shi S,et al.Clinical and animal research findings in pycnodysostosis and gene mutations of cathepsin K from 1996 to 2011[J/OL][J].Orphanet J Rare Dis,2011,6:20-
[2]Xue Y,Wang L,Xia D,et al.Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations[J].J Dent Res,2015,94(5):674-81
[3]Asagiri M,Hirai T,Kunigami T,et al.Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis[J].Science,2008,319(5863):624-627
[4]魏巍,孙文靖,于旸,等.人组织蛋白酶K基因研究进展[J].国际遗传学杂志,2012,35(2):82-85
[5]吕敏敏,张志勇.组织蛋白酶K与牙周炎的关系研究进展[J].河北医药,2011,33(5):750-752
[6]Mogi M,Otogoto J.Expression of cathepsin-K in gingival crevicular fluid of patients with periodontitis[J].Arch Oral Biol,2007,52(9):894-898
[7]Garg G,Pradeep AR,Thorat MK.Effect of nonsurgical periodontal therapy on crevicular fluid levels of Cathepsin K in periodontitis[J].Arch Oral Biol,2009,54(11):1046-1051
[8]Yamalik N,Gunday S,Kilinc K,et al.Analysis of cathepsin-K levels in biologic fluids from healthy or diseased natural teeth and dental implants[J].Int J Oral Maxillofac Implants,2011,26(5):991-997
[9]Yamalik N,Gunday S,Uysal S,et al.Analysis of cathepsin-K activity at tooth and dental implant sites and the potential of this enzyme in reflecting alveolar bone loss[J].J Periodontol,2012,83(4):498-505
[10]Strbac GD,Monov G,Cei S,et al.Cathepsin K levels in the crevicular fluid of dental implants: a pilot study[J].J Clin Periodontol,2006,33(4):302-308
[11]Ohba Y,Ohba T,Terai K,et al.Expression of cathepsin K mRNA during experimental tooth movement in rat as revealed by in situ hybridization[J].Arch Oral Biol,2000,45(1):63-69
[12]Tsuji Y,Yamaza T,Kido MA,et al.Expression of cathepsin K mRNA and protein in odontoclasts after experimental tooth movement in the mouse maxilla by in situ hybridization and immunoelectron microscopy[J].Cell T3 Res,2001,303(3):359-369
[13]Domon S,Shimokawa H,Matsumoto Y,et al.In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing t11 induced by tooth movement[J].Arch Oral Biol,1999,44(11):907-915
[14]Yoshimatsu M,Shibata Y,Kitaura H,et al.Experimental model of tooth movement by orthodontic force in mice and its application to tumor necrosis factor receptor-deficient mice[J].J Bone Miner Metab,2006,24(1):20-27
[15]Yamaguchi M,Hayashi M,Fujita S,et al.Low-energy laser irradiation facilitates the velocity of tooth movement and the expressions of matrix metalloproteinase-9,cathepsin K,and alpha(v) beta(3) integrin in rats[J].Eur J Orthod,2010,32(2):131-139
[16]Szumilo J,Burdan F,Zinkiewicz K,et al.Expression of syndecan-1 and cathepsins D and K in advanced esophageal squamous cell carcinoma[J].Folia Histochem Cytobiol,2009,47(4):571-578
[17]Kleer CG,Bloushtain-Qimron N,Chen YH,et al.Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression[J].Clin Cancer Res,2008,14(17):5357-5367
[18]Ishida M,Okabe H.Basaloid squamous cell carcinoma of the maxillary sinus: Report of two cases in association with cathepsin K expression[J].Oncol Lett,2013,5(6):1755-1759
[19]Bitu CC,Kauppila JH,Bufalino A,et al.Cathepsin K is present in invasive oral tongue squamous cell carcinoma in vivo and in vitro[J/OL][J].PLoS One,2013,8(8):e70925-
[20]Oshiro T,Shibasaki Y,Martin TJ,et al.Immunolocalization of vacuolar-type H+-ATPase,cathepsin K,matrix metalloproteinase-9,and receptor activator of NFkappaB ligand in odontoclasts during physiological root resorption of human deciduous teeth[J].Anat Rec,2001,264(3):305-311
[21]Linsuwanont B,Takagi Y,Ohya K,et al.Localization of cathepsin K in bovine odontoclasts during deciduous tooth resorption[J].Calcif T2 Int,2002,70(2):127-133
[22]Tsuchiya M,Akiba Y,Takahashi I,et al.Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar[J].Arch Histol Cytol,2008,71(2):89-100
[23]金星爱,吕晶,薛欣,等.组织蛋白酶K在大鼠磨牙再植术后牙髓中的表达[J].哈尔滨医科大学学报,2013,47(4):321-323
[24]Tsukamoto-Tanaka H,Ikegame M,Takagi R,et al.Histochemical and immunocytochemical study of hard t2 formation in dental pulp during the healing process in rat molars after tooth replantation[J].Cell T2 Res,2006,325(2):219-229
[25]Gao B,Chen W,Hao L,et al.Inhibiting periapical lesions through AAV-RNAi silencing of cathepsin K[J].J Dent Res,2012,92(2):180-186
[26]Arman A,Bereket A,Coker A,et al.Cathepsin K analysis in a pycnodysostosis cohort: demographic,genotypic and phenotypic features[J].Orphanet J Rare Dis,2014,9:60-
[27]Balaji MS,Sundaram RK,Karthik P,et al.Pycnodysostosis: A bone dysplasia with unusual oral manifestation[J].Indian J Dent,2014,5(4):218-221
[28]Cortisse N,Forget P,Dresse MF,et al.A case of osteosarcoma in a patient with pycnodysostosis[J].J PediatrHematol Oncol,2012,34(7):545-547
[29]Huang X,Qi X,Li M,et al.A Mutation in CTSK Gene in an Autosomal Recessive Pycnodysostosis Family of Chinese Origin[J]. Calcif T Int,2015.96(5):373-378
[30]Kyung SE,Horton JC.Papilledema from craniosynostosis in pycnodysostosis[J].Pediatr Neurol,2015,52(1):128-129
[31]Berenguer A,Freitas AP,Ferreira G,et al.A child with bone fractures and dysmorphic features: remember of pycnodysostosis and craniosynostosis[J/OL]. BMJ Case Rep,2012[2014.11.26].doi;10.1136/bcr-2012-006930
[32]Della Marca G,Scarano E,Leoni C,et al.Pycnodysostosis with extreme sleep apnea: a possible alternative to tracheotomy[J].Sleep Breath,2012,16(1):5-10
[33]Testani E,Scarano E,Leoni C,et al.Upper airway surgery of obstructive sleep apnea in pycnodysostosis: case report and literature review[J].Am J Med Genet A,2014,164A(8):2029-2035
[34]Girbal I,Nunes T,Medeira A,et al.Pycnodysostosis with novel gene mutation and severe obstructive sleep apnoea: management of a complex case[J/OL]. BMJ Case Rep,2013[2014.11.26].doi:10.1136/bcr-2013-200590
[35]Kshirsagar VY,Ahmed M,Nagarsenkar S,et al.Ichthyosis vulgaris and pycnodysostosis: an unusual occurrence[J].Acta Med Acad,2012,41(2):214-218
[36]Raposo-Amaral CE,Tong A,Denadai R,et al.A subcranial Le Fort III advancement with distraction osteogenesis as a clinical strategy to approach pycnodysostosis with midface retrusion and exorbitism[J].J Craniofac Surg,2013,24(4):1327-1330
[37]Caracas HP,Figueiredo PS,Mestrinho HD,et al.Pycnodysostosis with craniosynostosis: case report of the craniofacial and oral features[J].Clin Dysmorphol,2012,21(1):19-21
[38]Kamak H,Kamak G,Yavuz I.Clinical,radiographic,diagnostic and cephalometric features of pycnodysostosis in comparison with Turkish cephalometric norms: A case report[J].Eur J Dent,2012,6(4):454-459
[39]Kumar S.A patient with pycnodysostosis presenting with seizures and porencephaliccysts[J].J Neurosci Rural Pract,2014,5(3):284-6
[40]Ortegosa MV,Bertola DR,Aguena M,et al.Challenges in the orthodontic treatment of a patient with pycnodysostosis[J].Cleft Palate Craniofac J,2014,51(6):735-739
[41]Ozdemir TR,Atik T,Karaca E,et al.A novel mutation in two families with pycnodysostosis[J].Clin Dysmorphol,2013,22(3):102-105
[42]Farronato G,Salvadori S,Nolet F,et al.Pycnodysostosis: review and case report[J].Minerva Stomatol,2014,63(6):229-237
[43]S R,B PR,B S,et al.Osteomyelitis in pycnodysostosis - report of 2 clinical cases[J/OL][J].J Clin Diagn Res,2015,9(1):Z-D15