生物活性玻璃的抗菌性能及其在根管感染控制中的应用

摘要/Abstract

摘要： ［摘要］　生物活性玻璃（bioactive glasses，BG）是以CaO、SiO2、P2O5为主要成分的生物材料，具有良好的生物活性、生物相容性、抗菌和诱导骨形成性能，已广泛应用于骨组织工程、整形外科及牙科学等领域。BG对金黄色葡萄球菌、大肠杆菌、绿脓杆菌等常见致病菌，以及血链球菌、伴放线聚集杆菌(Aggregatibacter actinomycetemcomitans, Aa)、牙龈卟啉单胞菌等口腔特有的需氧菌和厌氧菌均有良好的抗菌性能。介孔生物活性玻璃（mesoporous bioactive glasses，MBG）是一种新型的BG，内部有高度有序的介孔通道，较BG更高的比表面积和孔容积，更佳的生物相容性和诱导组织细胞分化成骨能力。MBG独特的介孔结构可携带抗菌剂或金属离子，实现缓释，发挥长期的抗菌作用。

关键词: 生物活性玻璃, 抗菌, 根管感染

Abstract: Abstract: The bioactive glass (BG) is a kind of biomaterial based on CaO-SiO2-P2O5 composition, which has excellent bioactivity, biocompatibility, osteoconductivity and antibacterial properties. It has been widely applied in bone tissue engineering, plastic surgery, dentistry and other fields. BG has good antibacterial property not only for common pathogenic bacteria such as S. aureus, E. coli and P.aeruginosa, but also for some oral bacterium of aerobic and anaerobic bacteria such as S.sanguis, Aa and P. gingivalis. The mesoporous Bioactive Glass (MBG) is a new type of BG, which possesses a highly ordered mesoporous channel, higher specific surface area and pore volume, better biocompatibility, osteoconductivity and osteogenesis. The unique mesoporous structure of MBG can deliver antibacterial agents or metal ions, which releases slowly and gives play to long-term antibacterial effects.

Key words: bioactive glasses, antibacterial, root canal infection

中图分类号:

R781.05

朱洁吴大明刘卫红. 生物活性玻璃的抗菌性能及其在根管感染控制中的应用[J]. , 2016, 36(6): 566-568.

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