应用非刺激性全唾液法进行慢性牙周炎患者种植短期预后的评价

›› 2017, Vol. 37 ›› Issue (4): 350-355.

应用非刺激性全唾液法进行慢性牙周炎患者种植短期预后的评价

李晶¹,张琴²,石莹²,姚源²,何惠宇²

1. 新疆医科大学
2. 新疆医科大学第一附属医院

收稿日期:2016-11-15 修回日期:2016-12-07 出版日期:2017-04-28 发布日期:2017-04-11
通讯作者: 何惠宇 E-mail:hehuiyu01@126.com
基金资助:
新疆乌鲁木齐市科技局科学技术计划项目（厅局级）

Evaluation of the short term prognosis of implant patients with chronic periodontitis using whole unstimulated saliva

Received:2016-11-15 Revised:2016-12-07 Online:2017-04-28 Published:2017-04-11

摘要/Abstract

摘要： 目的探究经过治疗的慢性牙周炎患者能否同牙周健康者一样获得良好的种植短期预后。方法将经过系统性牙周治疗的轻中度慢性牙周炎患者设为试验组，牙周健康者为对照组，在种植前和种植后1个月、3个月收集患者唾液，检查种植体稳定性和牙周状况，ELISA法检测唾液中的IL-1β、IL-17、TNF-α。结果 ISQ、IL-1β、IL-17、TNF-α表达量3次检查结果有区别，差异有统计学意义（P<0.05）。试验组的IL-1β、IL-17、TNF-α表达量结果高于对照组，差异有统计学意义（P<0.05）；进一步分析，试验组第3个月检测结果与对照组初始结果无统计学差异（P>0.05）。试验组和对照组组间的PD、ISQ检查结果无统计学差异（P>0.05）。试验组和对照组的初期稳定性结果无统计学差异（P>0.05）。结论在短时间内观察，种植术后经过治疗的牙周炎患者炎症因子水平降低，并且同牙周健康者一样有良好的种植体稳定性。即排除咬合负载因素，轻中度牙周炎患者同样可以取得良好的种植预后。

关键词: 种植体, 非刺激性全唾液, 共振频率分析, 慢性牙周炎

Abstract: Objective To explore the treatment of patients with chronic periodontitis and periodontal health as well as to obtain a good shortterm prognosis. Methods The patients with mild to moderate chronic periodontitis after periodontal treatment were designed as the experimental group， the periodontal healthy subjects as control group. 1 month and 3 months before planting and after planting saliva of patients was collected， the stability of implants and periodontal status were examined， and saliva was determined by enzymelinked immunosorbent assay (ELISA) in IL-1， IL-17 and TNF-α. Results The expressions of ISQ， IL-1， IL-17 and TNF-α in three examinations were different， and the difference was statistically significant (P<0.05). In experimental group， the expressions of IL-1 beta， IL-17 and TNF-α were higher than those in the control group， and the difference was significant (P<0.05). In further analysis， the results of the experimental group in 3 months showed no statistically significant difference with the initial results of the control group (P>0.05). There was no significant difference in PD and ISQ between the experimental group and the control group (P>0.05). Experimental group and control group showed no statistical difference in initial stability (P>0.05). Conclusion In shorttime observation， after implant treatment the inflammatory factor levels of periodontitis patients decrease， and have good implant stability as the periodontal healthy patients. With occlusal load factors excluded， patients with mild to moderate periodontitis can also get good implant prognosis.

Key words: implant, whole unstimulated saliva, resonance frequency analysis, chronic periodontitis

中图分类号:

R783.4

李晶张琴石莹姚源何惠宇. 应用非刺激性全唾液法进行慢性牙周炎患者种植短期预后的评价[J]. , 2017, 37(4): 350-355.

参考文献

[1]Bhatavadekar N.Helping the clinician make evidence-based implant selectionsA system atic revi ew and qualitative analysis of dental implant studies over a 20 2010 period[J].. Int Dent J,2010,60(5):359-369
[2].谢昊．牙周病的流行病学[M]．北京：北京大学医学出版社,2006：29
[3]Wiebe CB,Putllins EE.The periodontal disease classification system of the American Academy of Periodontology—an update[J].Can Dent Assoc,2000,66(11):594-759
[4]Pataro AL,Costa FO,Cortelli SC,et al.Association between severity of body mass index and periodontal condition in women[J].Clin Oral Investig,2012,16(3):727-734
[5]Rhodus NL,Cheng B,Myers S,et al.A comparison of the pminflammatory,NF-kappaB-dependent cylokinea：TNF-alpha,IL-l-alpha,IL-6,and IL-8 in different oral fluids from oral lichen planus patients[J].J Clin Immunol,2005,114(3):278-283
[6]孟焕新.牙周病学[M].4版.人民卫生出版社,2012:130-135,335-337
[7]阮征.共振频率分析在口腔种植实验与临床中的应用[J].口腔材料器械,2010,19(3):157-160
[8]程兴群,邓盟,周学东,等.唾液和唾液组学与疾病早期诊断[J].国际口腔医学杂志,2014,41(2):213-219
[9]柴琳,詹渊博,宋雪静,等.牙周基础治疗对慢性牙周炎患者非刺激性全唾液、龈沟液及血清中基质金属蛋白酶-9水平的影响[J].国际免疫学杂志,2014,37(6):531-539
[10]武影,束蓉,刘宏伟.慢性牙周炎患者和健康者非刺激性全唾液中的差异蛋白比较[J].华西口腔医学杂志,2011,29(5):519-525
[11]Ebersole JL， Schuster JL，Stevens J,et al.Patterns of salivary analytes provide diagnostic capacityfor distinguishing chronic adult periodontitis from health[J].J Clin Immunol,2013,33(1):271-279
[12]Nitika M,Sushma C,Om Prakash K,et al.A study of interleukin 1β levels in peri-miniscrew crevicular fluid (PMCF)[J].Progress in Orthodontics,2014,15(1):2-7
[13]Beklen,A,Ainola,M.Hukkanen,et alMMPs,IL-1,and TNF are regulated by IL-17 in periodontitis[J].. J Dent Res,2007,86(4):347-351
[14]Sato K,Suematsu A,Okamoto K,et al.Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction[J].J Exp Med,2006,203(12):2673-2682
[15]胡赞,郑雷蕾,唐甜,等.正畸微种植体周围炎对骨结合界面影响的研究[J].华西口腔医学杂志,2011,29(1):17-26
[16]杨少强,廖旭辉,顾为望,等.牙周炎犬种植体周围炎动物模型建立[J].口腔医学,2011,31(12):746-750
[17]和璐,李蓬,沙月琴,等.代谢综合征患者与健康者唾液中肿瘤坏死α、白细胞介素1β水平比较[J].中华口腔医学杂志,2010,45(5):269-273
[18]高少怀,段海英,李智勇,等.实验性种植体周围炎龈沟液中IL-10和IL-17的分析[J].口腔医学研究,2012,28(7):648-655
[19]吴小吉,林野,邱屯新,等.应用共振频率评估种植稳定性的临床研究[J].中国口腔种植学杂志,2005,10(2):73-78
[20]Rabel A，K?hler SG,Schmidt-Westhausen AM.Clinical study on the primary stability of two dental implant systems with resonance frequency analysis[J].Clin Oral Invest,2007,11(3):257-265
[21]王瑶,耿威,谭包生,等.亲水性大颗粒喷砂酸蚀表面种植体骨愈合期的共振频率分析及早期负荷临床探讨[J].口腔医学研究,2012,28(7):694-698
[22]鲍琰,肖立群,施斌,等.Straumann种植体骨愈合期稳定性变化的临床动态监测[J].口腔医学研究,2009,25(6):739-741