口腔鳞状细胞癌中Slug及E-cadherin的表达

›› 2017, Vol. 37 ›› Issue (3): 214-218.

口腔鳞状细胞癌中Slug及E-cadherin的表达

王舒仪,郑彩云,林思思,施更生

温州医科大学附属台州医院

收稿日期:2016-06-14 修回日期:2016-07-21 出版日期:2017-03-28 发布日期:2017-04-12
通讯作者: 施更生 E-mail:shigs@enzemed.com
基金资助:
台州市医学会研究基金项目

The expressions of Slug and E-cadherin in oral squamous cell carcinoma

Received:2016-06-14 Revised:2016-07-21 Online:2017-03-28 Published:2017-04-12

摘要/Abstract

摘要： ［摘要］目的探讨口腔鳞状细胞癌（OSCC）中Slug及E-cadherin表达及差异性。方法收集口腔鳞癌标本30例，正常口腔黏膜组织20例，使用rt-PCR的方法检测Slug及E-cadherin mRNA的表达情况，分析其病理特征相关性。结果口腔鳞癌组织中Slug的表达高于正常口腔黏膜组织（P<0.05），而口腔鳞癌组织中E-cadherin的表达低于正常口腔黏膜组织（P<0.05），Slug和E-cadherin表达与TNM分期、淋巴结是否转移相关（P<0.05）,而与性别、年龄、细胞分化程度、肿瘤浸润大小无关（P>0.05）。结论口腔鳞状细胞癌中Slug和E-cadherin 的表达与肿瘤的发展、侵袭、转移密切相关。

关键词: Slug, E-cadherin, EMT, 口腔鳞状细胞癌

Abstract: Objective　 To investigate the expressions and the differences of Slug and E-cadherin in oral squamous cell carcinoma（OSCC）. Methods: The mRNA levels of Slug and E-cadherin in 30 cases of OSCC tissues and 20 cases of oral mucosa tissues were detected by rt-PCR, then the relationship between the expression and pathological features was analyzed. Results: The expression of Slug in OSCC tissues was higher than in oral mucosa tissues （P<0.05）while the expression of E-cadherin in OSCC tissues was lower than in oral mucosa tissues （P<0.05）.The expressions of Slug and E-cadherin had correlation with TNM stage and lymph node metastasis（P<0.05）, but not with gender, age, cell differentiation degree and deeper invasion（P＞0.05）. Conclusion: The expressions of Slug and E-cadherin in OSCC are closely related to the development , invasion and metastasis of the tumor.

Key words: Slug, E-cadherin, EMT, oral squamous cell carcinoma

中图分类号:

R739.85

王舒仪郑彩云林思思施更生. 口腔鳞状细胞癌中Slug及E-cadherin的表达[J]. , 2017, 37(3): 214-218.

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