Abstract: The physiological, biochemical and behavioral periodic oscillations of the living organisms are called circadian rhythm, which is regulated by the clock genes. Recently, dozens of core clock genes have been found. As the earliest known clock genes，Clock and Bmal1 are the starting factors of the entire circadian system. On the other side, bone remodeling is an effective method to solve bone defect, which is one of the most important issues in prosthodontics nowadays. Thus this review summarized the basic mechanism of the clock genes, and explored the regulatory mechanism of clock gene（Clock and Bmal1） on bone remodeling in recent research progress.