GBR技术与种植相关的研究进展

摘要/Abstract

摘要： 种植修复已经成为牙列缺损的一种重要修复方式，但临床工作中常会碰到患者因为牙周炎、牙槽突局部吸收等因素导致骨量不足，而无法进行种植修复。近年来兴起的引导骨组织再生（guided bone regeneration,GBR）技术有效地促进了骨组织再生，解决了骨量不足的问题，扩大了种植的适应范围。而GBR膜是决定GBR技术临床效果的主要因素之一，也是该领域的关注重点。本文就GBR技术在种植修复的临床应用、GBR膜的分类与研究方向等方面做一综述。

关键词: 引导骨组织再生技术, 种植, GBR膜

Abstract: Nowadays, implant prosthesis has become an essential way to repair the defect of dentition. However, there are many patients who cannot be implanted in clinical procedure because of bone defect caused by periodontitis and local bone absorption. In recent years, guided bone regeneration (GBR) has become an effective therapy to promote bone regeneration, which solves the problem of inadequate alveolar bone and expands the indication of implant technique. GBR membrane is not only one of the main factors to determine the clinical result of GBR, but also the focus of the field. This article discussed the clinical application of GBR in implant prosthesis, the classification and the development trend of GBR membrane. 

Key words: GBR, implant, GBR membrane

中图分类号:

R783.4

徐丽娜王琛. GBR技术与种植相关的研究进展[J]. , 2017, 37(9): 829-832.

参考文献

[1]马士卿, 张旭, 孙迎春, 等.引导骨组织再生膜的研究进展[J].口腔医学研究, 2016, 32(3):308-310
[2]Melcher AH.On the repair potential of periodontal tissues[J].J Periodontol, 1976, 47(5):256-260
[3]Dahlin C, Sennerby L, Lekholm U, et al.Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits[J].Int J Oral Maxillofac Implants, 1989, 4(1):19-25
[4]邓旭, 田霞.引导骨再生膜技术治疗牙周骨缺损的临床应用研究[J].中国医疗前沿月刊, 2010, 5(13):65-65
[5]Jung RE, Fenner N, Hmmerle CHF, et al.Longterm outcome of implants placed with guided bone regeneration (GBR) using resorbable and nonresorbable membranes after 1214 years[J].Clin Oral Implants Res, 2013, 24(10):1065-1073
[6]John V, De PR, Blanchard S.Socket preservation as a precursor of future implant placement: review of the literature and case reports[J].Compend Contin Educ Dent, 2007, 28(12):646-653
[7]Sheikh Z, Qureshi J, Alshahrani AM, et al.Collagen based barrier membranes for periodontal guided bone regeneration applications[J].Odontology, 2017, 105(1):1-12
[8]吴群, 陈必胜, 姜晓钟, 等.膜引导组织再生技术应用于即刻种植的实验研究[J].实用口腔医学杂志, 2013, 29(1):28-30
[9] Parashis AO, Kalaitzakis CJ, Tatakis DN, et al .Alveolar ridge preservation using xenogeneic collagen matrix and bone allograft［J］. Int J Dent, 2014, 2014:172854.
[10]朱宸佑, 邓佳, 曹钰彬, 等.生物膜在位点保护中的应用[J].国际口腔医学杂志, 2016, 43(2):187-189
[11]范倩倩, 柳忠豪.种植体周围炎治疗及重新骨结合的研究[J].中国口腔种植学杂志, 2013, 18(4):210-215
[12]Sahrmann P, Attin T, Schmidlin PR.Regenerative treatment of periimplantitis using bone substitutes and membrane: a systematic review[J].Clin Implant Dent Relat Res, 2011, 13(1):46-57
[13]Schwarz F，John G，Becker J.Reentry after combined surgical resective and regenerative therapy of advanced periimplantitis：a retrospective analysis of five cases[J].Int J Periodontics Restorative Dent, 2015, 35(5):647-653
[14]Froum SJ, Froum SH, Rosen PS.Successful management of periimplantitis with a regenerative approach: a consecutive series of 51 treated implants with 3 to 75year followup[J].Int J Periodontics Restorative Dent, 2012, 32(1):11-20
[15]吴新, 夏金星, 薛昌敖, 等.保留修复体采用技术治疗种植体周围炎的临床研究[J].口腔医学, 2014, 34(3):231-232
[16]Pinheiro ML, Moreira TC, FeresFilho EJ.Guided bone regeneration of a pronounced gingivoalveolar cleft due to orthodontic space closure[J].J Periodontol, 2006, 77(6):1091-1095
[17]Lee MJ, Kim BO, Yu SJ.Clinical evaluation of a biphasic calcium phosphate grafting material in the treatment of human periodontal intrabony defects[J].J Periodontal Implant Sci, 2012, 42(4):127-135
[18]Bottino MC, Thomas V.Membranes for periodontal regenerationa materials perspective［J］. Front Oral Biol, 2015, 17:90-100.
[19]Bottino MC, Thomas V, Janowski GM.A novel spatially designed and functionally graded electrospun membrane for periodontal regeneration[J].Acta Biomater, 2011, 7(1):216-24
[20]Li WJ, Jr CJ, Mauck RL, et al.Fabrication and characterization of six electrospun poly(alphahydroxy ester)based fibrous scaffolds for tissue engineering applications[J].Acta Biomater, 2006, 2(4):377-385
[21]Fu YC, Nie H, Ho ML, et al.Optimized bone regeneration based on sustained release from threedimensional fibrous PLGAHAp composite scaffolds loaded with BMP2[J].Biotechnol Bioeng, 2008, 99(4):996-1006
[22]Phipps MC, Clem WC, Catledge SA, et al.Mesenchymal stem cell responses to bonemimetic electrospun matrices composed of polycaprolactone,collagen I and nanoparticulate hydroxyapatite[J].PloS One, 2011, 6(2):e16813-
[23]李蒙蒙, 朱瑛, 仰大勇, 等.静电纺丝纳米纤维薄膜的应用进展［J］. 高分子通报, 2010(9):44-53.
[24]李岩, 仇天宝, 周治南, 等.静电纺丝纳米纤维的应用进展[J].材料导报, 2011, 25(17):84-88
[25]李智慧, 何小凤, 李运刚.功能梯度材料的研究现状[J].河北联合大学学报自然科学版, 2007, 29(1):45-50
[26]Bottino MC, Thomas V, Schmidt G, et al.Recent advances in the development of GTRGBR membranes for periodontal regeneration—A materials perspective[J].Dent Mater, 2012, 28(7):703-21
[27]Norowski PA, Babu J, Adatrow PC, et al.Antimicrobial activity of minocyclineloaded genipincrosslinked nanofibrous chitosan mats for guided tissue regeneration[J].J Biomed Mater Res A, 2012, 3(4):528-532
[28]Li S, Zhang Y, Mony U.Biomaterials for periodontal regeneration: A review of ceramics and polymers[J].Biomatter, 2011, 2(4):271-277
[29]Chang PC, Dovban AS, Lim LP, et al.Dual delivery of PDGF and simvastatin to accelerate periodontal regeneration in vivo[J].Biomaterials, 2013, 34(38):9990-9997
[30]Behring J, Junker R, Walboomers XF, et al.Toward guided tissue and bone regeneration: morphology,attachment,proliferation,and migration of cells cultured on collagen barrier membranesA systematic review[J].Odontology, 2008, 96(1):1-11
[31]Soldatos NK, Stylianou P, Koidou VP, et al.Limitations and options using resorbable versus nonresorbable membranes for successful guided bone regeneration[J].Quintessence Int, 2017, 48(2):131-147
[32]Kannan AL, Bose BB, Muthu J, et al.Efficacy of combination therapy using anorganic bovine bone graft with resorbable GTR membrane vsopen flap debridement alone in the management of grade II furcation defects in mandibular molarsA comparative study[J].J Int Soc Prev Community Dent, 2014, 4(1):38-43