肿瘤坏死因子-α在正畸牙移动中作用的研究进展

摘要/Abstract

摘要： 肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）为一种单核细胞因子，参与体内的炎症反应，同时在核因子κ B受体活化因子配体的共同作用下可以促进破骨细胞的形成。正畸牙齿移动是在机械应力作用下牙周组织与骨组织共同改建的过程，需要破骨细胞与成骨细胞及其他牙周因子共同作用。正畸治疗过程中，在正畸力的作用下牙周组织会处于轻微炎症的状态，产生的各种炎症因子对牙周组织改建有促进作用。其中TNF-α在正畸牙齿移动过程中发挥着重要作用，能够促进破骨细胞形成，同时对成骨细胞的形成也有一定影响。本文对肿瘤坏死因子-α在正畸牙齿移动中作用的研究进展进行综述。

关键词: 肿瘤坏死因子α, 牙移动, 破骨细胞, 正畸力

Abstract: Tumor necrosis factor-α is a monocyte factor involved in the inflammatory response in vivo and can promote osteoclast formation under the combined action of Receptor activator for Nuclear Factor-κ B Ligand.Orthodontic tooth movement is the process of periodontal tissue and bone remodeling under mechanical stress, which requires osteoclast and osteoblast and other periodontal factors. During orthodontic treatment, under the influence of orthodontic force, periodontal tissue will be in a state of mild inflammation, and various inflammatory factors produced can promote periodontal tissue remodeling. Tumor necrosis factor-α plays an important role in orthodontic tooth movement and can promote osteoclast formation, and also has some effects on the formation of osteoblasts. This review summarizes the progress in the study of the role of TNF-α in orthodontic tooth movement.

Key words: Tumor necrosis factor-α , tooth movement, osteoclast, orthodontic force

中图分类号:

R780.2

王琳璇李永明邱亚孙立众马文强韩梅米方林. 肿瘤坏死因子-α在正畸牙移动中作用的研究进展[J]. , 2018, 38(7): 648-652.

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