MMP-14在口腔癌患者预后及转移的临床病理学研究

›› 2018, Vol. 38 ›› Issue (8): 685-689.

MMP-14在口腔癌患者预后及转移的临床病理学研究

毕也¹,周童¹,贾颜鸿¹,徐召南¹,赵轩一²,张泽兵¹

1. 吉林大学口腔医院
2. 通化市卫生学校

收稿日期:2017-12-04 修回日期:2017-12-27 出版日期:2018-08-28 发布日期:2018-08-20
通讯作者: 张泽兵 E-mail:382653167@qq.com
基金资助:
自噬在口腔癌CAL27细胞顺铂耐药中的作用机制研究

A clinicopathological study of the prognosis and metastasis of MMP-14 in oral cancer patients

Received:2017-12-04 Revised:2017-12-27 Online:2018-08-28 Published:2018-08-20

摘要/Abstract

摘要： 目的观察基质金属蛋白酶14（MMP-14）、波形蛋白\E-钙粘蛋白在口腔癌及癌旁组织中的表达，探讨MMP-14在口腔癌患者预后及转移的作用机制。方法选取83例有随访资料的口腔癌患者标本和20例癌旁组织标本，应用免疫组织化学法检测MMP-14及EMT标记物Vimentin，E-cadherin的表达水平，结合随访患者临床参数，进行统计学分析。结果 MMP-14表达在口腔癌中较正常组织升高，有特别显著性差异(P＜0.01)；在有淋巴结转移、中低分化及T3-T4期患者中高表达，有特别显著性差异（P<0.01）；且与Vimentin上调，E-cadherin下调具有显著相关性（P<0.001）。结论 MMP-14的高表达，提示口腔癌患者生存率低预后较差，易发生淋巴结转移。其机制可能通过对EMT的调控，从而促进口腔癌细胞的侵袭转移。

关键词: 口腔鳞状细胞癌, 基质金属蛋白酶14, 上皮间充质转化, 免疫组织化学

Abstract: Objective To study the expressions of MMP-14 (matrix metalloproteinase-14), Vimentin and E-cadherin in oral squamous cell carecinoma (OSCC) and to investigate the relationship between MMP-14, Vimentin and E-cadherin expression and pathologic diagnosis, clinicopathogical features and prognosis. Methods The expression levels of MMP-14, Vimentin and E-cadherin were tested by immunohistochemical in 83 cases of OSCC and 20 in adjacent normal tissues, and statistical analysis was conducted according to the clinical parameters of follow-up patients. Results The expression level of MMP-14 protein in the OSCC tissue was significantly higher than that in the surrounding normal tissue (P<0.01). In OSCC tissue, the MMP-14 expression was positively correlated with lymph node metastasis(P<0.01), low differentiated degree(P<0.05), and the T3-T4 tumor stage(P<0.05). MMP-14 showed significant positive correlation with Vimentin, and negative correlation with E-cadherin (P<0.01). Conclusion This study has found the close relationship between high expression of MMP-14 in oral carcinoma and the recurrence and prognosis. Epithelial-mesenchymal transition may promote invasion and metastasis of oral carcinoma, and MMP-14 promotes EMT.

Key words: oral squamous cell carcinoma, MMP-14, EMT, immunohistochemistry

中图分类号:

R730.2

毕也周童贾颜鸿徐召南赵轩一张泽兵. MMP-14在口腔癌患者预后及转移的临床病理学研究[J]. , 2018, 38(8): 685-689.

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