Abstract: Objective：To analyze the serum liver enzymes and uric acid in patients with oral lichen planus, and discuss the correlation between these indexes and OLP. Method：A retrospective analysis was made of 157 OLP patients in the stomatology department of Jiangsu Stomatological Hospital and Suqian people's Hospital of Nanjing drum-tower hospital group as the study group and 169 healthy subjects as the control group. The levels of serum liver enzymes and uric acid in the two groups were detected. Independent sample t-test and chi-square test were used for inter-group analysis, and unconditional logistic regression analysis was used to analyze the relationship between related indexes and the incidence of OLP. Results： There was no significant difference in the expression of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatine phosphate kinase (CK) between the two groups. The level of lactic dehydrogenase (LDH) in OLP patients was higher than that in control group, while the level of uric acid (UA) was lower than that in control group. The difference between the two groups was statistically significant (p < 0.05), logistic regression analysis showed that serum LDH and UA was correlated with incidence of OLP. Conclusion： The serum LDH level increased and the UA level decreased in patients with OLP, which may be used as biomarkers for monitoring and follow-up of OLP.