口腔扁平苔藓合并2型糖尿病的临床及病理特征研究

doi:10.13591/j.cnki.kqyx.2022.09.007

口腔医学 ›› 2022, Vol. 42 ›› Issue (9): 802-806.doi: 10.13591/j.cnki.kqyx.2022.09.007

口腔扁平苔藓合并2型糖尿病的临床及病理特征研究

李凯一¹, 何汶秀¹, 任晓萌¹, 罗海燕², 李春蕾¹, 华红¹

1.北京大学口腔医学院·口腔医院黏膜科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔数字化医疗技术和材料国家工程实验室,北京(100081);
2.北京大学口腔医学院·口腔医院口腔病理研究室,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔数字化医疗技术和材料国家工程实验室,北京(100081)

修回日期:2022-03-31 出版日期:2022-09-28 发布日期:2022-09-20
通讯作者: 华红 E-mail:honghua1968@aliyun.com 李春蕾 E-mail:chunlei2021@163.com
基金资助:
国家自然科学基金(81730030);北京大学口腔医院青年科研基金(PKUSS20180104)

Clinical and histopathological characteristics of oral lichen planus patients with type 2 diabetes mellitus

LI Kaiyi, HE Wenxiu, REN Xiaomeng, LUO Haiyan, LI Chunlei, HUA Hong

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing 100081,China

Revised:2022-03-31 Online:2022-09-28 Published:2022-09-20

摘要/Abstract

摘要： 目的通过病例对照研究分析口腔扁平苔藓(oral lichen planus, OLP)合并2型糖尿病(type 2 diabetes mellitus,T2DM)的临床及组织病理学表现特征。方法将104例患者分为OLP组与OLP+T2DM组。收集患者的基本信息,OLP的临床类型与REU评分,两位病理专家对组织病理表现进行具体描述。应用SPSS 24.0对两组间的临床与组织病理表现进行统计分析。结果 OLP+T2DM组糜烂型OLP的发生率与REU评分均显著高于OLP组(P＜0.001)。随访1个月后,服用降糖药物(P＜0.001)和血糖控制理想(P＜0.01)的OLP患者REU评分均显著降低。多因素二元 Logistic 回归分析显示:高REU评分、糜烂型、淋巴细胞浸润密集、淋巴浸润带不清晰、基底层重度炎症、基底层纤维蛋白的存在(OR=1.58、37.15、8.49、10.16、3.94、4.35)是OLP合并T2DM的典型特征。结论合并T2DM的OLP患者临床病损更严重,组织破坏程度更高,临床诊治应制定个性化方案,以获得精准治疗效果。

关键词: 口腔扁平苔藓, 2型糖尿病, 病例对照研究, 临床表现, 组织病理学

Abstract: Objective To analyze the clinical and histopathological characteristics of oral lichen planus (OLP) complicated with type 2 diabetes mellitus (T2DM) through case-control study. Methods One hundred and four patients were divided into OLP group and OLP+T2DM group and their basic information, clinical types and REU scores of OLP were collected. Histopathological manifestations were described by two pathologists. Clinical and histopathological manifestations between the two groups were analyzed by SPSS 24.0. Results The prevalence of erosive OLP and REU score in OLP+T2DM group were significantly higher than those in OLP group (P＜0.001). After one month follow-up, REU score of OLP patients taking hypoglycemic drugs decreased significantly (P＜0.001), and that of OLP patients with ideal blood glucose control (P＜0.01) decreased significantly. Logistic regression analysis showed that: high REU score, erosion type, dense lymphocyte infiltration, unclear lymphocyte infiltration zone, severe inflammation in the basal layer, and presence of fibrin in the basal layer (OR=1.58, 37.15, 8.49, 10.16, 3.94, 4.35) were typical characteristics of OLP with T2DM. Conclusion OLP patients with T2DM have more severe clinical lesions and higher degree of tissue destruction. A personalized plan should be made to obtain better treatment effect.

Key words: oral lichen planus, type 2 diabetes mellitus, case-control study, clinical characteristic, histopathology

中图分类号:

R781.59

李凯一, 何汶秀, 任晓萌, 罗海燕, 李春蕾, 华红. 口腔扁平苔藓合并2型糖尿病的临床及病理特征研究[J]. 口腔医学, 2022, 42(9): 802-806.

LI Kaiyi, HE Wenxiu, REN Xiaomeng, LUO Haiyan, LI Chunlei, HUA Hong. Clinical and histopathological characteristics of oral lichen planus patients with type 2 diabetes mellitus[J]. Stomatology, 2022, 42(9): 802-806.

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口腔扁平苔藓合并2型糖尿病的临床及病理特征研究

Clinical and histopathological characteristics of oral lichen planus patients with type 2 diabetes mellitus

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