口腔癌的侵袭前缘及外科根治策略

doi:10.13591/j.cnki.kqyx.2022.11.001

口腔医学 ›› 2022, Vol. 42 ›› Issue (11): 961-965.doi: 10.13591/j.cnki.kqyx.2022.11.001

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口腔癌的侵袭前缘及外科根治策略

张陈平, 王磊

上海交通大学医学院附属第九人民医院口腔颌面头颈肿瘤科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海(200011)

收稿日期:2022-08-26 出版日期:2022-11-28 发布日期:2022-11-25
通讯作者: 张陈平 E-mail:zhang.chenping@hotmail.com
作者简介:张陈平,主任医师、二级教授、博士研究生导师、享受国务院特殊津贴专家。现任上海交通大学口腔医学院口腔颌面外科系主任、爱丁堡皇家外科学院头颈肿瘤与修复培训中心主任、中华口腔医学会口腔颌面头颈肿瘤专委会主任委员、中国抗癌协会头颈肿瘤专委会主任委员。长期致力于口腔颌面头颈肿瘤的基础与临床研究,擅长中、晚期恶性肿瘤的外科治疗及颌面部缺损的功能重建。率先提出了功能导向的颌骨重建策略,在国际上首创牙种植牵引“一体化”技术,创立颌骨功能重建理论体系,牵头制定了颌骨重建的专家共识。获得国家科技进步二等奖2项(2019年第一,2007年第三);上海市科技进步一等奖3项(2010年第一,2019年第三,2006年第三);中华医学科技进步二等奖1项(2006年第一)。培养博士后、博士和硕士研究生63名,在国内外主办学习班百余期,累计培养专科人才近3 000名。主编专著4部,参编专著10余部,全国统编教材《口腔颌面外科学》及《口腔颌面头颈肿瘤学》副主编,承担国家自然科学基金和上海市重大项目等省部级以上课题27项,以第一作者、通信作者发表论文190余篇,其中SCI论文80余篇。近年来获得全国优秀科技工作者、全国白求恩式好医生、上海工匠、上海十佳医生、上海市医德楷模、上海市领军人才和上海市优秀学科带头人等殊荣。
基金资助:
上海市科委课题(15411950300,YDZX20173100004422);上海市申康发展中心课题(16CR2004A,SHDC2020CR3008A)

Tumor invasive front of oral cancer and radical surgery strategies

ZHANG Chenping, WANG Lei

Department of Oral Maxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China

Received:2022-08-26 Online:2022-11-28 Published:2022-11-25

摘要/Abstract

摘要： 手术彻底性切除是口腔癌治疗的关键和难点。肿瘤浸润深度、肿瘤出芽及特有的肿瘤微环境决定了肿瘤侵袭前缘的肿瘤细胞生物学特性,对于侵袭和转移具有决定性作用。间室切除对于强化口腔癌外科治疗的根治力度,具有重要意义。该文对口腔癌侵袭前缘的意义及相关临床策略的新进展进行了分析与评述。

关键词: 口腔癌, 侵袭前缘, 肿瘤浸润深度, 间室切除

Abstract: Radical resection isthe key for treatment of oral cancer. Depth of invasion, tumour budding and the tumour microenvironment define the biological characteristics of cells in tumor invasive front, thereby determining invasion and metastasis capabilities. Compartmental resection is an important method for oral cancer treatment. Through analysis and review of the cutting-edge research on tumor invasive front, this paper sheds light on optimal radical resection for oral cancer.

Key words: oral cancer, tumor invasive front, depth of invasion, compartmental resection

中图分类号:

R782
R739.85

张陈平, 王磊. 口腔癌的侵袭前缘及外科根治策略[J]. 口腔医学, 2022, 42(11): 961-965.

ZHANG Chenping, WANG Lei. Tumor invasive front of oral cancer and radical surgery strategies[J]. Stomatology, 2022, 42(11): 961-965.

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口腔癌的侵袭前缘及外科根治策略

Tumor invasive front of oral cancer and radical surgery strategies

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