布地奈德混悬液雾化吸入治疗口腔手术全麻术后咽痛的疗效分析

›› 2016, Vol. 36 ›› Issue (1): 61-63.

布地奈德混悬液雾化吸入治疗口腔手术全麻术后咽痛的疗效分析

程喆¹,郑晚来²,占适龙³,叶建青³,朱雪美²,陈华丽²,颜晶晶²

1. 浙江松阳亿佳口腔门诊部
2. 浙江丽水市人民医院
3. 丽水市人民医院口腔医院

收稿日期:2014-11-18 修回日期:2015-01-21 出版日期:2016-01-28 发布日期:2016-01-08
通讯作者: 程喆 E-mail:chengzhezj@126.com

Analyzing curative effects of budesonide suspension inhalation in the treatment of postoperative sore throat after oral operation under general anesthesia

Received:2014-11-18 Revised:2015-01-21 Online:2016-01-28 Published:2016-01-08

摘要/Abstract

摘要： 目的　探讨布地奈德混悬液雾化吸入治疗口腔手术全麻术后咽痛的临床疗效。方法　随机选择经口气管内插管的口腔全麻手术患者89例分为两组，观察组药物应用布地奈德混悬液雾化吸入治疗，对照组药物应用庆大霉素+α糜蛋白酶+地塞米松雾化吸入治疗，均为每日两次，术后连续3 d每天末次治疗后记录患者咽痛主诉，按照PrinceHenry评分法进行疼痛程度的评价，比较两组患者咽痛情况。结果　观察组与对照组之间患者经治疗后术后咽痛缓解程度存在统计学差异（P＜0.05），观察组术后咽痛缓解效果优于对照组。结论　口腔手术全麻患者术后使用布地奈德混悬液雾化吸入治疗能够有效缓解术后咽痛。

关键词: 布地奈德, 雾化吸入, 口腔, 全麻, 术后咽痛

Abstract: Objective To study the curative effects of budesonide suspension inhalation in the treatment of postoperative sore throat after oral operation under general anesthesia. Methods 89 patients having oral operations under general anesthesia with orotracheal intubation were randomly selected and divided into two groups, namely the observation group which applied budesonide inhalation therapy and the control group applying gentamicin + alpha chymotrypsin + dexamethasone inhalation therapy. Both groups conducted the therapy twice a day. Patients’ complaints of postoperative sore throat were recorded after the second therapy for 3 consecutive days. The degree of sore was evaluated according to Prince - Henry score, and the results were compared between groups. Results Significantly different between groups regarding the degree of ease of postoperative sore throat (P<0.05), the relieving effect in the observation group were better than that in the control group. Conclusion Budesonide atomization inhalation treatment can relieve postoperative sore throat after oral operation under general anesthesia.

Key words: Budesonide, Atomization inhalation, Oral, General anesthesia, Postoperative sore throat

中图分类号:

R782
R614

程喆郑晚来占适龙叶建青朱雪美陈华丽颜晶晶. 布地奈德混悬液雾化吸入治疗口腔手术全麻术后咽痛的疗效分析[J]. , 2016, 36(1): 61-63.

参考文献

[1]孙衍庆.[J].宋鸿钊,邱蔚六,等.现代手术并发症学[M].西安：世界图书出版司,2003,:-
[2] 赵俊.疼痛诊断治疗学[M].郑州：河南大学出版社， 1999:212
[3]闵静，张燕，葛超.气管插管喉损伤分析[J].临床军医杂志,2008,3(36):150-151
[4]Biro P,Seifert B,Pasch T.Complaints of sore throat after tracheal intubation: a prospective evaluation[J].Eur J Anaesthesiol,2005,22(4):307-311
[5]Park SH,Han SH,Do SH,et al.Prophylactic dexamethasone decreases the incidence of sore throat and hoarseness after tracheal extubation with a double-lumen endobronchial tube[J].Anesth Analg,2008,107(6):1814-1818
[6]Chan L,Lee ML,Lo YL.Postoperative sore throat and katamine gargle[J].Br J Anaesth,2010,105(1):97-
[7] Park SY,KIM SH,Lee AR,et al.Prophylactic effect of dexamethasone in reducing postoperative sore throat[J].2010,58(1):15-9
[8]Hung NK,Wu CT,Chan SM,et al.The effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride,10% lidocaine,and 2% lidocaine[J].Anesth Analg,2010,111(4):882-886
[9]Huang YS,Hung NK,Lee MS,et al.The effectiveness of benzy-damine hydrochloride spray on the endotracheal tube cuff or oral mucosa for postoperative sore throat[J].Anesth Analg,2010,111(4):887-891
[10]Tazeh-kand NF,Eslami B,Mohammadian K.Inhaled fluticasone propionate reduces postoperative sore throat,cough and hoarseness[J].Anesth Analg,2010,111(4):895-898
[11]Honma K,Kamachi M,Akamatsu Y,et al.Lidocaine spray 10 min prior to intubation:effects on postoperative sore throat[J].J Anesth,2010,24(6):962-965
[12]焦亮，刘瑞昌.地佐辛和氟比洛芬酯用于颌面外科手术全身麻醉气管插管术后咽痛的比较[J].北京大学学报（医学版,2014,46(1):104-106
[13]蒋亦红，谭毅.插管全麻术后喉部并发症的原因探析[J].临床和实验医学杂志,2009,1(8):57-59
[14] 杨媛华.雾化吸入给药误区[J].中国全科医学，2010.13（20）：58
[15] 李明华，殷凯生，董克成.哮喘病药物治疗学[M].北京：人民卫生出版社，2001:177
[16]申波.布地奈德雾化吸入治疗急性感染性喉炎，喉气管、支气管炎疗效观察[J].中国实用医药,2013,8(20):189-190
[17]Pearson JP,Parikh S,Orlando RC,et al.Review article：reflux and its consequences the laryngeal,pulmonary and oesophageal manifestationsConference held in conjunction with the 9th International Symposium on Human Pepsin(ISHP)Kingston-upon-Hull,UK,21-23 April 2010[J]..Aliment Pharmacol Ther,2011,33(Suppl1):S1-71
[18]李斌，邱晓东，尹宁，等.布地奈德混悬液喷雾预防全麻插喉罩后急性感染性咽喉炎的临床研究[J].中华医院感染学杂志,2014,24(18):4601-4603
[19]李伟伟，李杰，于峰.布地奈德气雾剂超量使用致真菌性口炎1例[J].实用医药杂志,2011,28(6):544-
[20]李秀丽，杨书环，任师磊.布地奈德气雾吸入后行碳酸氢钠口腔护[J].菏泽医学专科学校学报,2013,25(4):66-67
[21]Brattsand R,et al.The Role of Intracellular Esterification in Budesonide Once-Daily Dosing and Airway Selectivity[J].Clin Ther,2003,25:28-
[22]陈燕青，王家东，徐雅男，等.布地奈德雾化吸入对全身麻醉气管插管术后咽喉部并发症的缓解作用[J].上海交通大学学报（医学版,2014,31(12):1746-1749