初级纤毛对牙发育的作用及相关机制的研究进展

›› 2016, Vol. 36 ›› Issue (10): 950-952.

初级纤毛对牙发育的作用及相关机制的研究进展

张晨洋¹,孙瑶²

1. 同济大学附属口腔医院
2. 同济大学口腔医学院

收稿日期:2016-05-17 修回日期:2016-06-23 出版日期:2016-10-28 发布日期:2016-10-25
通讯作者: 孙瑶 E-mail:Sunyao919@126.com
基金资助:
国家自然基金;国家自然基金

Research progress of the mechanism and function of primary cilium on tooth development

Chen-Yang ZHANG,

Received:2016-05-17 Revised:2016-06-23 Online:2016-10-28 Published:2016-10-25

摘要/Abstract

摘要： 摘要：初级纤毛是哺乳动物细胞表面特化的细胞突起，其内部存在大量调控细胞生命活动的信号分子，参与构成细胞内的信息传递系统。近年来研究发现，牙组织细胞有纤毛存在，并且纤毛病患者可同时伴有牙齿发育异常表现。说明细胞纤毛可能参与牙发育过程。本文旨在将近年来国内外有关初级纤毛在牙齿发育中的功能及作用机制研究进展作一综述，阐示细胞纤毛中信号分子的功能及作用通路，拓展对牙发育机制的了解。

关键词: 初级纤毛, 牙齿发育, Hh信号通路, Wnt信号通路

Abstract: Abstract: The primary cilium is a specialized cellular process of mammalian cells. With a large amount of cell signal molecules in it, the primary cilium forms a large information system in cells. Recently, primary cilium has been found in tooth forming cells, and it is reported that dysfunction of cilium can cause dysplasia of teeth，which suggests primary cilium is involved in tooth development. In order to demonstrate the function and signaling pathways of the cilium in tooth development, research on the mechanism and function of primary cilium will be reviewed. It may broaden our understanding of the molecular mechanisms underlying tooth development.

Key words: Primary Cilium, Tooth development, Hh signaling, Wnt signaling

中图分类号:

张晨洋孙瑶. 初级纤毛对牙发育的作用及相关机制的研究进展[J]. , 2016, 36(10): 950-952.

Chen-Yang ZHANG. Research progress of the mechanism and function of primary cilium on tooth development [J]. , 2016, 36(10): 950-952.

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