基质细胞衍生因子和甲状旁腺激素在组织再生中的作用

摘要/Abstract

摘要： ［摘要］趋化因子是原位组织工程中最具有应用前景的趋化剂，基质细胞衍生因子（stromal cell derived factor-1， SDF-1）是重要的趋化因子之一，能通过趋化募集机体自身表达基质细胞衍生因子-1（CXCL12）的特异受体（C-X-C chemokine receptor type 4， CXCR4）CXCR4的干细胞到达创伤区域，促进组织再生。甲状旁腺激素（parathyroid hormone， PTH）作为唯一得到美国食品和药物管理局（Food and Drug Administration，FDA）批准的用于治疗骨质疏松的骨合成代谢药物，能够动员骨髓基质细胞进入血液，并抑制蛋白二肽基肽酶-IV（dipeptidyl peptidase-IV，DPP-IV）对SDF-1的降解。二者联合应用可以发挥对干细胞的推和拉的双向效应以促进干细胞的募集、归巢，从而达到协同促进组织再生的作用。本文就SDF-1和PTH在组织再生中的作用做出综述。

关键词: PTH , SDF-1/CXCR4 , DPP-IV/CD26 , 组织再生

Abstract: Chemokines are the most promising chemotactic agents of in situ tissue engineering. As one of the most important chemokines, stromal cell derived factor-1(SDF-1) can facilitate the chemotaxis and migration of stem cells expressing C-X-C chemokine receptor type4 (CXCR4) to the site of injury to promote tissue regeneration. Approved by the U. S. Food and Drug Administration (FDA), parathyroid hormone (PTH) is the unique bone anabolic drug for the treatment of osteoporosis, which can mobilize stem cells from bone marrow into circulation and prevent the proteolytic cleavage of SDF-1 by inhibiting the specific protease dipeptidyl peptidase-IV (DPP-IV). The dual effect of pushing and pulling on stem cells mediated by the combination of PTH and SDF-1 can recruit and home stem cells to promote tissue regeneration. This article made a brief review on the effects of SDF-1 and PTH on tissue regeneration.

Key words: PTH , SDF-1/CXCR4 , DPP-IV/CD26 , tissue regeneration

冯瑞娟葛少华. 基质细胞衍生因子和甲状旁腺激素在组织再生中的作用[J]. , 2016, 36(2): 182-185.

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