RNAi的作用机制及其在口腔医学领域的研究进展

›› 2016, Vol. 36 ›› Issue (5): 471-474.

RNAi的作用机制及其在口腔医学领域的研究进展

葛奕辰,陆文昕,李燕

四川大学华西口腔医学院

收稿日期:2015-11-09 修回日期:2016-02-29 出版日期:2016-05-28 发布日期:2016-06-01
通讯作者: 李燕 E-mail:408385250@qq.com
基金资助:
EB病毒介导细胞DNA应激沉默和端粒酶TCAB1转录激活的效应及信号调控

Mechanism and application of RNA interference in stomatology

Received:2015-11-09 Revised:2016-02-29 Online:2016-05-28 Published:2016-06-01

摘要/Abstract

摘要： [摘要] RNA干扰(RNA interference , RNAi)是由双链RNA诱发的使特定序列基因沉默的现象，存在小干扰RNA(siRNA)和微小RNA (miRNA)两种不同的途径，主要有转录水平基因沉默，转录后水平基因沉默和翻译水平基因沉默三种机制，具有高效性和高特异性的特点。本文就RNAi的途径、技术路线及RNA干扰在牙齿发育、唇腭裂研究、牙周组织和口腔肿瘤中的研究进展作一综述。

关键词: RNA干扰, 小干扰RNA, 微小RNA, 基因沉默, 口腔医学

Abstract: Abstract: RNA interference (RNAi) is a sequence-specific gene silencing phenomena mediated by double-stranded RNA which involves siRNA (Small interfering RNA) and miRNA (Micro RNA), and it could block gene expression at the level of transcription, post-transcription and translation, with high efficiency and specificity. This review summarized the pathway and technical route, and the application of RNAi in maxillofacial development, cheilopalatognathus researches, periodontal tissue development and oral tumor researches in stomatology.

Key words: RNAi (RNA interference), siRNA( Small interfering RNA), miRNA (Micro RNA), gene silence, stomatology

中图分类号:

RR394.2/R78

葛奕辰陆文昕李燕. RNAi的作用机制及其在口腔医学领域的研究进展[J]. , 2016, 36(5): 471-474.

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