牙周基础治疗对口腔扁平苔藓患者血清中白细胞介素10及转化生长因子β的影响

摘要/Abstract

摘要： 目的　通过对口腔扁平苔藓伴牙周炎患者牙周基础治疗,观察其对患者血清中白细胞介素10(interleukin10,IL10)及转化生长因子β(TGFβ）水平的影响，进而探讨牙周干预在口腔扁平苔藓患者治疗的意义。方法　将40例口腔扁平苔藓伴牙周炎患者分为牙周治疗组（20例）和非牙周治疗组（20例），两组分别给予牙周基础治疗联合药物治疗及单纯药物治疗。分别在治疗前后观察两组患者探诊深度（probing depth,PD）、附着丧失(attachment loss, AL) 及出血指数（bleeding index，BI）情况，并采用酶联免疫吸附法检测两组患者在治疗前后血清中IL10及TGFβ的水平。结果　牙周治疗组治疗后除AL外PD及BI均低于治疗前 (P＜0.05）。非牙周治疗组治疗前后PD及AL相比差异无统计学意义（P>0.05），而非牙周治疗组治疗后BI高于治疗前（P＜0.05）；牙周基础治疗组治疗后血清中TGFβ表达水平低于该组治疗前水平，差异具有统计学意义（P＜0.05），而IL10在牙周基础治疗前后无明显差异（P>0.05）。非牙周治疗组在治疗前后患者血清中IL10及TGFβ表达水平差异无统计学意义（P>0.05）。结论　牙周基础治疗可影响OLP患者血清TGFβ水平。牙周基础治疗作为OLP患者控制其症状发展的辅助治疗方法之一，其远期效果及作用机制值得进一步观察研究。

关键词: 口腔扁平苔藓, 牙周炎, 牙周基础治疗, 转化生长因子β, 白介素-10

Abstract: Abstract Objective To investigate the effect of the periodontal basic therapy on patients with both oral lichen planus(OLP) and periodontitis through observation of the levels of interleukin-10 and transforming growth factor-β (TGF-β) in serum before and after treatment, and to discuss the meaning of periodontal intervention in the treatment of oral lichen plan. Methods: 40 patients with both OLP and periodontitis were divided into two groups: periodontal treatment group (20 patients) and non-periodontal treatment group (20 patients), then the two groups were given periodontal therapy combined with drug therapy and drug treatment only, respectively. Probing depth (PD), attachment loss (AL), bleeding indices (bleeding index,BI) and levels of IL-10 and TGF-β were detected at the baseline and one month after treatment. Results After treatment, PD and BI except AL were lower than before treatment (P<0.05) in periodontal treatment group. There were no significant differences in PD and AL in non-periodontal treatment group before and after treatment (P>0.05); in contrast, BI after treatment was higher than before treatment (P<0.05). In periodontal treatment group, the expression level of TGF-β in serum decreased after treatment and the difference was statistically significant (P<0.05); however, the level of IL-10 had no significant difference before and after periodontal treatment (P>0.05). The levels of IL-10 and TGF-β had no statistically significant differences before and after treatment in non-periodontal treatment group (P>0.05).Conclusion The periodontal basic therapy can affect the level of TGF-β in the serum of patients with both OLP and periodontitis. Periodontal basic treatment can be used as one of the auxiliary treatment to control the disease development, but the long-term effect is worth further observation. Conclusion: The periodontal basic therapy can affect the serum level of TGF-β in patients with both OLP and periodontitis, periodontal basic treatment can be used as one of the auxiliary treatment to control the disease development, but the long-term effect is worth further observation.

Key words: Oral Lichen Planus, Periodontitis, Periodontal basic therapy, TGF-β, Interleukin-10

中图分类号:

R781.05

张瑞敏詹渊博张弘驰闫颖. 牙周基础治疗对口腔扁平苔藓患者血清中白细胞介素10及转化生长因子β的影响[J]. , 2017, 37(1): 53-56.

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