长链非编码RNA在骨发育中作用的研究进展

›› 2017, Vol. 37 ›› Issue (3): 271-275.

长链非编码RNA在骨发育中作用的研究进展

魏玉¹,孙瑶²

1. 同济大学口腔医学院口腔医学专业
2. 同济大学口腔医学院

收稿日期:2016-09-02 修回日期:2016-09-23 出版日期:2017-03-28 发布日期:2017-04-12
通讯作者: 孙瑶 E-mail:Sunyao919@126.com
基金资助:
国家重点研发计划课题;高等学校博士学科专项科研基金;上海市卫生和计划生育委员会科研课题;国家自然基金

Research progress of the roles of lncRNAs in bone development

Yu WEI,

Received:2016-09-02 Revised:2016-09-23 Online:2017-03-28 Published:2017-04-12

摘要/Abstract

摘要： ［摘要］长链非编码RNA(Long noncoding RNAs，lncRNAs)是指长度大于200 nt、缺少开放阅读框（ORFs）的非编码RNA，其占非编码RNA的很大比例。长链非编码RNA在表观遗传、转录、翻译以及蛋白质修饰过程中发挥重要的调控作用, 从而广泛地参与包括细胞分化、个体发育等在内的重要生命过程。同时越来越多的研究发现它也与人类某些重要疾病发生和发展密切相关。该文综述了lncRNAs在骨发育中的作用。

关键词: 长链非编码RNA（Long non-coding RNAs,lncRNAs）, 骨发育, 骨疾病

Abstract: Long non-coding RNAs(lncRNAs) refer to the non-coding RNAs which exceed 200nt in length and lack open reading frames, and they account for a significant proportion of non-coding RNAs. LncRNAs play an important role in regulating the process of epigenetics, transcription, translation and protein modification, thus they widely participate in some important life processes including cell differentiation, individual development and so on. At the same time, more and more studies have found that lncRNAs are also closely related to the occurrence and development of some important human diseases. In this paper, the roles of lncRNAs in bone development will be reviewed.

Key words: Long non-coding RNAs(lncRNAs), bone development, bone diseases

中图分类号:

Q522

魏玉孙瑶. 长链非编码RNA在骨发育中作用的研究进展[J]. , 2017, 37(3): 271-275.

Yu WEI. Research progress of the roles of lncRNAs in bone development[J]. , 2017, 37(3): 271-275.

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