microRNAs在骨代谢中的研究进展

摘要/Abstract

摘要： ［摘要］ microRNAs(miRNAs)是在真核生物中发现的一类内源性的具有调控功能的非编码RNA，参与了各种重要的细胞生物学过程。研究表明miRNAs能够调控成骨细胞，破骨细胞，软骨细胞和成脂分化，维持骨形成和骨吸收的平衡，是生物器官发育和某些骨代谢疾病的重要调控因子，该文就在这些方面的研究进展作一综述。

关键词: 小分子RNA；成骨细胞；破骨细胞；软骨细胞；成脂；骨质疏松症；骨关节炎

Abstract: MicroRNAs(miRNAs) was found in eukaryotes, which has the function of regulation and control of a class of endogenous non-coding RNA, and participates in a variety of important cytobiology processes. Current literature indicates that miRNAs can regulate the differentiation and bone absorption. They also regulate the ossification of cartilage. Therefore, miRNAs are powerful regulators for biological organ development and some metabolic bone diseases. In this paper, the research progress of these aspects is summarized.

Key words: microRNA；Osteoblast；osteoclast；Chondrocyte；Adipogenic；osteoporosis；osteoarthritis

中图分类号:

Q522

李多多王志峰蓝菁. microRNAs在骨代谢中的研究进展[J]. , 2017, 37(3): 276-280.

参考文献

[1]Sacchetti B,Funari A,Michienzi S,et al.Self-renewing osteoprogenitors inbone marrow sinusoids can organize a hematopoietic microenvironment[J].Cell,2007,131(2):324-336
[2]Lin GL,Hankenson KD.Integration of BMP,Wnt and notch signaling pathways in osteoblast differentiation[J].J Cell Biochem,2011,112(12):3491-3501
[3]Chen G,Deng C,Li YP.TGF-beta and BMP signaling in osteoblast differentiation and bone formation[J].Int J Biol Sci,2012,8(2):272-288
[4]Lagos-Quintana M,Rauhut R,Lendeckel W,et al.Identification of novel genes coding for small expressed RNAs[J].Science,2001,294(5543):853-858
[5]Lewis BP,Shih IH,Jones-Rhoades MW,et al.Prediction of mammalian microRNA targets[J].Cell,2003,115(7):787-798
[6]Bosse GD,Simard MJ.A new twist in the microRNA pathway: not Dicer but Argonaute is required for a microRNA production[J].Cell Res,2010,20(7):735-737
[7]Lai EC.Micro RNAs are complementary to 3'UTR sequence motifs thatmediate negative post-transcriptional regulation[J].Nature genetics,2002,30(4):363-364
[8]Lagos-Quintana M,Rauhut R,Meyer J,et al.New microRNAs from mouse and human[J].RNA,2003,9(2):175-179
[9]Lai EC,Tomancak P,Williams RW,et al.Computational identification of Drosophila microRNA genes[J].Genome biology,2003,4(7):R42-
[10]Girijadevi R,Sreedevi VC,Sreedharan JV,et al.IntmiR: a completecatalogue of intronic miRNAs of human and mouse[J].Bioinformation,2011,5(10):458-459
[11]Li Z,Hassan MQ,Jafferji M,et al.Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation[J].J Biol Chem,2009,284(23):15676-15684
[12]Kapinas K,Kessler CB,Delany AM.miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling[J]. J Biol Chem.2009,108(1): 216-224
[13]Franceschetti,T.Kessler,CB. Lee,S.K. Delany,A.M. miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration[J].. J Biol Chem,2013,288(46):33347-33360
[14]Zhang J,Tu Q,Bonewald LF,et al.Effects of miR-335-5p in modulating osteogenic differentiation by specifically down-regulating Wnt antagonist DKK1[J].J Bone MinerRes,2011,26(8):1953-1963
[15]Chen S,Yang L,Jie Q,et al.Liu MicroRNA 125b suppresses the proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells[J].J Mol Med Rep,2014,9(5):1820-1826
[16]Mizuno Y,Yagi K,Tokuzawa Y,et al.miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation[J].Biochem Biophys Res Commun,2008,368(2):267-272
[17]Eskildsen T,Taipaleenmaki H,Stenvang J,et al.MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells invivo[J].Proc Natl Acad Sci USA,2011,108(15):6139-6144
[18]Hassan MQ,Gordon JA,Beloti MM,et al.A network connecting Runx2,SATB2,and the miR-23a~27a~24-2 cluster regulates theosteoblast differentiation program[J].Proc Natl Acad Sci USA,2010,107(46):19879-19884
[19]Eskildsen T,Taipaleenmaki H,Stenvang J,et al.MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivoProceedings of the National Academy of Sciences of the United States of America[J].. Science,2011,108(15):6139-6144
[20]Young SR,Gerard-O'Riley R,Kim JB,et al.Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts[J].J Bone MinerRes,2009,24(3):411-424
[21]Huang J,Zhao L,Xing L,et al.MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation[J].Stem Cells,2010,28(2):357-364
[22]Chen Q,Liu W,Sinha KM,et al.Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix[J].PloS one,2013,8(3):e58104-
[23]Zhang J,Tu Q,Bonewald LF,et al.Effects of miR-335-5p in modulating osteogenic differentiation by specifically down-regulating Wnt antagonist DKK1[J].Cell,2011,26(8):1953-1963
[24]Huang J,Zhao L,Xing L,et al.microRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation[J].Stem Cells,2010,28(2):357-364
[25]Xie Y,Zhang L,Gao Y,Ge W,Tang P.The multiple roles of microrna-223 in regulating bone metabolism[J].Molecules,2015,20(10):19433-19448
[26]Chen C,Cheng P,X ie H,et a1.m iR-503 regulates osteoclastogenesis via targeting RANK[J].J Bone MinerRes,2014,29(2):338-347
[27]Qu,B; Xia,X; Yan,M; Gong,K; Deng,S; Huang,G.; Ma,Z; Pan,XmiR-218 is involved in the negative regulation of osteoclastogenesis and bone resorption by partial suppression of p38MAPK-c-Fos-NFATc1signaling[J].. Exp Cell Res,2015,338(1):89-96
[28]Mann M,Barad O,Agami R,et al.miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate[J].Proc Natl Acad Sci USA,2010,107(36):15804-15809
[29]Kobayashi T,Lu J,Cobb BS,et al.Dicer-dependent pathways regulate chondrocyte proliferation and differentiation[J].Cell,2008,105(6):1949-1954
[30]Miyaki S,Sato T,Inoue A,et al.MicroRNA-140 plays dual roles in both cartilage development and homeostasis[J].Genes Dev,2010,24(11):1173-1185
[31]Lin EA,Kong L,Bai XH,et al.miR-199a,a bone morphogenic protein 2-responsive MicroRNA,regulates chondrogenesis via direct targeting to Smad1[J].Biol Chem,2009,284(17):11326-11335
[32]Yang B,Guo H,Zhang Y,et al.MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9[J].PLOS ONE,2011,6(7):e21679-
[33]Han J,Yang T,Gao J,et al.Specific microRNA expression during chondrogenesis of human mesenchymal stem cells[J].Int J Mol Med,2010,25(3):377-384
[34]Esau C,Kang X,Peralta E,et al.MicroRNA-143 regulates adipocyte differentiation[J].J Biol Chem,2004,279(50):52361-52365
[35]Yang Z,Bian C,Zhou H,et al.MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose t2-derived mesenchymal stem cells through adenovirus EID-1[J].Stem Cells Dev,2011,20(2):259-267
[36]Sun F,Wang J,Pan Q,et al.Characterization of function and regulation of miR-24-1 and miR-31[J].Biochem Biophys Res Commun,2009,380(3):660-665
[37]Hamam D,Ali D,Vishnubalaji R,Al-Nbaheen M,Aldahmash A,Kassem M.and Alajez NMmicroRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (Skeletal) stem cells[J].. Cell Death Dis,2014,5:1499-
[38]Tang P,Xiong Q,Ge W,Zhang L.The role of microRNAs in osteoclasts and osteoporosis[J].RNA Biology,2014,11(11):1355-1363
[39]Zhao X,Xu D,Li Y,et al.MicroRNAs regulate bone metabolism[J] J Bone and Mineral Metabolism,2014,32(3):221-231
[40]Pilgram TK,Hildebolt CF,Dotson M,Cohen SC,Hauser JF,Kardaris E,Civitelli Relationships between clinical attachment level and spine and hip bone mineral density: data from healthy postmenopausal women[J].J Periodontol,2012,73(3):298-301
[41]Liao L,Yang X,Su X,et al.Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow[J].Cell Death Dis,2013,4:600-
[42]Li H,Xie H,Liu W,et al.A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans[J].J clin investigation,2009,119(12):3666-3677
[43]Hu R,Liu W,Li H,Yang L,Chen C,Xia ZY,Guo LJ,Xie H,Zhou HD,Wu XP,Luo XH A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation[J].J Biol Chem,2011,286(14):12328-12339
[44]Jopling CL,Yi M,Lancaster AM,et al.Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA[J].Science,2005,309(5740):1577-1581
[45]Jones SW,Watkins Q Le Good N,et al.The identification of differentially expressed microRNA in osteoarthritic t4 that modulate the production of TNF-alpha and MMP13[J].Osteoarthritis and cartilage,2009,17(4):464-472