PRP及PRP/OAM对种植体周围骨缺损修复的实验研究

›› 2017, Vol. 37 ›› Issue (4): 302-306.

PRP及PRP/OAM对种植体周围骨缺损修复的实验研究

王毅¹,刘杨²,杜军³,胡杨⁴

1. 新疆医科大学附属中医医院
2. 新疆医科大学第六附属医院口腔科
3. 新疆医科大学附属中医医院口腔科
4. 新疆医科大学第一附属医院

收稿日期:2016-09-01 修回日期:2016-10-15 出版日期:2017-04-28 发布日期:2017-04-11
通讯作者: 王毅 E-mail:waithth@163.com
基金资助:
新疆维吾尔自治区自然科学基金

Experimental study of repair of bone defect around implant with PRP and PRP/OAM

Received:2016-09-01 Revised:2016-10-15 Online:2017-04-28 Published:2017-04-11

摘要/Abstract

摘要： 目的探讨富血小板血浆（PRP）以及PRP复合骨诱导活性材料（PRP/OAM）对种植体周围骨缺损修复的作用。方法选取成年Beagle犬4只，体质量10～13 kg，每只犬左右两侧下颌第四前磨牙牙位随机分为A组和B组，与B组同侧的第一、二前磨牙牙位作为对照组。A组种植体周围骨缺损区植入PRP/OAM，B组植入PRP/磷酸三钙，对照组植入磷酸三钙。采用能谱分析各组种植体-新骨界面Ca2+含量，同时观察各组种植术后8、16周组织学形态。结果 A组和B组种植术后8、16周时种植体部位骨表面Ca2+含量均明显高于对照组（P<0.05）；A组种植术后8、16周时种植体部位骨表面Ca2+含量为（26.01±3.28）%和（44.10±7.11）%，明显高于B组（P<0.05）；种植术后8周，A组新骨与种植体形成区段性骨结合，B组种植体边缘可有新骨形成，对照组种植体边缘为纤维性界面；种植术后16周，A组和B组新骨与种植体形成骨整合，对照组仅为纤维性结合。结论 PRP及PRP/OAM在种植体周围骨缺损修复中，能有效促进骨缺损修复。

关键词: 种植牙, 骨缺损, 富血小板血浆, 骨诱导活性材料, 犬

Abstract: Objective To investigate the effect of rich platelet plasma (PRP) and PRP composite osteoinduction active material (PRP/OAM) on the repair of bone defect around implant. Methods Four adult Beagle dogs were selected which weight 10 ~ 13 kg， and each dogs left and right mandibular fourth molar teeth were randomly divided into group A and group B， the first and second molar teeth in the same side with group B as control group. In group A， bone defect around the implant was implanted with PRP/OAM， group B was implanted with PRP/ calcium phosphate， and the control group was implanted with calcium phosphate. The contents of Ca2+ on the implant bone interface of each group were analyzed by energy spectrum， and the histological patterns of 8 and 16 weeks after implantation were observed. Results Ca2+ content on the planting body bone surface of group A and group B planting after 8 and 16 weeks was significantly higher than that of the control group (P<0.05); Ca2+ content on the planting body bone surface of group A planting after 8， 16 weeks were (26.01±3.28)% and (44.10±7.11)%， which were significantly higher than that in group B (P<0.05); 8 weeks after implantation， in group A new bone and implant formed sectional osseointegration， in group B new bone formed at the implant edge， and the control group implant edge was fibrous interface; 16 weeks after implantation， in group A and group B new bone and implant formed bone integration， in the control group it was only fibrous combination. Conclusion PRP and PRP/OAM in the repair of bone defects around implants can effectively promote the repair of bone defects.

Key words: dental implant, bone defect, rich platelet plasma, osteoinduction active material, dog

中图分类号:

R782.1

王毅刘杨杜军胡杨. PRP及PRP/OAM对种植体周围骨缺损修复的实验研究[J]. , 2017, 37(4): 302-306.

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