慢性牙周炎与阿尔茨海默病相关性研究进展

摘要/Abstract

摘要： 慢性牙周炎是由菌斑微生物引起的牙周支持组织破坏的慢性感染性疾病，是造成我国成人失牙的最主要原因。随着牙周医学的兴起，牙周炎和全身性疾病的相互关系成为研究热点。阿尔茨海默病是一种常见的引起老年人群痴呆的神经退行性病变。慢性牙周炎和阿尔茨海默病都是以多种炎症介质参与的炎症反应为关键病理机制，该文就二者的特点及相互关联机制作一综述。

关键词: 慢性牙周炎, 阿尔茨海默病, 炎症介质, 认知障碍

Abstract: Chronic periodontitis (CP) is a kind of chronic infectious diseases caused by plaque microbial， which can destroy the periodontal tissues and is the main cause of adults tooth loss in our country. It has been a research hotspot to explore the relationship between chronic periodontitis and systemic diseases with the development of periodontal medicine. Alzheimer disease (AD) is one of the most common causes of elderly dementia neural degenerative diseases. The key pathomechanism of CP and AD is inflammatory response triggered by various inflammatory mediators. This article will review the characteristics and the mechanism of the interaction between the two diseases.

Key words: chronic periodontitis, Alzheimer disease, inflammation mediators, cognition disorders

中图分类号:

R781.4+2/R749.1+6

张静周薇宋忠臣. 慢性牙周炎与阿尔茨海默病相关性研究进展[J]. , 2017, 37(4): 364-368.

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