代谢组学在口腔癌及口腔癌前病变标志物研究中的应用

摘要/Abstract

摘要： 口腔癌是最常见的头颈部恶性肿瘤，可由口腔白斑等口腔癌前病变发展而来。因为缺少早期筛查及检测的肿瘤生物标记物，50%以上的口腔癌患者在晚期阶段才能得到确诊，发现可用于口腔癌早期诊断的肿瘤标志物正成为研究热点。基于代谢组学技术的分析方法具有发现肿瘤相关标志物的潜能，越来越多的用于重大疾病的风险预评估及早期诊断等方面的研究。该文对代谢组学的理论基础、检测技术及其在口腔癌和癌前病变标志物研究中的应用作一综述。

关键词: 代谢组学, 口腔癌, 口腔癌前病变, 肿瘤标志物

Abstract: The oral cancers are the most common tumors in the head and neck cancers.They can be developed from oral leukoplakia and other oral precancerous lesions. Due to the lack of biomarkers for early detection and risk assessment， more than 50% patients are often diagnosed at the late stage. The discovery of tumor markers for early diagnosis of oral carcinomas is becoming a hot research issue.The analysis method based on the metabolomics technology has the potential to come up with tumorassociated biomarkers. Metabonomics becomes a hot spot in the research of pathological mechanism， clinical diagnosis and prediction of diseases. This paper reviews the theoretical basis and techniques of metabonomics and its application in the metabolomics technology in its way into the biomarker discovery of the oral cancers and oral precancerous lesions.

Key words: metabolomics, oral cancers, oral precancerous lesion, tumor biomarkers

中图分类号:

R739.85

于雪迪孙红英. 代谢组学在口腔癌及口腔癌前病变标志物研究中的应用[J]. , 2017, 37(4): 369-372.

Yu XueDi. Application of metabolomics in study on biomarkers for oral carcinoma and oral precancerous lesions[J]. , 2017, 37(4): 369-372.

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