低水平激光治疗促进正畸牙齿移动的研究进展

摘要/Abstract

摘要： 低水平激光治疗（low-level laser therapy ，LLLT）是被FDA批准应用于临床的一种安全、无创的治疗方法，可通过使用600-1000nm的单色可见红光或近红外光对细胞和组织产生光生物刺激作用。目前，LLLT广泛应用于促进伤口愈合，缓解疼痛，减少炎症，再生医学等领域。现有研究认为，LLLT的分子和细胞机制主要与线粒体电子呼吸链有关，通过促进ATP的生成，调节细胞新陈代谢。大量研究表明，LLLT可通过促进牙周膜和牙槽骨的生理性改建，加速牙齿移动，进而缩短正畸治疗时间。由于LLLT的光生物刺激作用、非侵入性方式等特点使其在加速正畸牙齿移动方面有广泛的应用前景。本文就LLLT的作用机制,生物学效应及对正畸治疗中牙齿移动的促进作用进行探讨。

关键词: 低水平激光治疗, 光生物调节作用, 正畸牙齿移动, 细胞色素氧化酶C

Abstract: Low-level laser therapy (LLLT) is a safe, noninvasive technology that is approved by the FDA for clinical use. It can produce photobiostimulate on cells and tissues by using 600-1000 nm monochromatic red or near-infrared light. At present, LLLT has been widely applied to promoting the wound healing, relieving pain, reducing inflammation and regenerative medicine et al. It is believed that the molecular and cellular mechanisms of LLLT are mainly related to the respiratory chain of mitochondrion. In this way, mitochondrion are responsible for the cellular metabolism by promoting the formation of ATP. A large number of studies have shown that LLLT can reduce the orthodontic treatment duration and accelerate tooth movement by promoting the physiological alteration of periodontal ligament and alveolar . Because of the photobiostimulating and noninvasive way, LLLT has wide application prospect in accelerating orthodontic tooth movement. This review will cover the mechanism of LLLT , biological effects and its positive effect on orthodontic tooth movement.

Key words: lowlevel laser therapy（LLLT）, photobiomodulation（PBM）, orthodontic tooth movement（OTM）, CCO

中图分类号:

R783.5

王晓琨赵忠琪彭慧敏王小晋梁家迪刘畅. 低水平激光治疗促进正畸牙齿移动的研究进展[J]. , 2018, 38(8): 756-760.

参考文献

[1]Huang H, Williams RC, Kyrkanides S.Accelerated orthodontic tooth movement: molecular mechanisms[J].Am J Orthod Dentofacial Orthop, 2014, 146(5):620-632
[2]Limpanichkul W, Godfrey K, Srisuk N, et al.Effects of lowlevel laser therapy on the rate of orthodontic tooth movement[J].Orthod Craniofac Res, 2006, 9(1):38-43
[3]Yassaei S, Aghili H, Afshari JT, et al.Effects of diode laser (980 nm) on orthodontic tooth movement and interleukin 6 levels in gingival crevicular fluid in female subjects[J].Lasers Med Sci, 2016, 31(9):1751-1759
[4]Matsumoto T, Iimura T, Ogura K, et al.The role of osteocytes in bone resorption during orthodontic tooth movement[J].J Dent Res, 2013, 92(4):340-345
[5]Scribante A, Sfondrini MF, Gatti S, et al.Disinclusion of unerupted teeth by mean of selfligating brackets: Effect of blood contamination on shear bond strength[J].Med Oral Patol Oral Cir Bucal, 2013, 18(1):e162-e167
[6]Gracco A, Stellini E, Parenti SI, et al.Individualized orthodontic treatment: The Insignia system[J].Orthodontics (CHIC.), 2013, 14(1):e88-E94
[7]Sekhavat AR, Mousavizadeh K, Pakshir HR, et al.Effect of misoprostol,a prostaglandin E 1 analog,on orthodontic tooth movement in rats[J].Am J Orthod Dentofacial Orthop, 2002, 122(5):542-547
[8]Liu ZJ, King GJ, Gu GM, et al.Does human relaxin accelerate orthodontic tooth movement in rats?[J].Ann NY Acad Sci, 2005, 1041(1):388-394
[9]Kale S, Kocadereli I, Atilla P, et al.Comparison of the effects of 1,25 dihydroxycholecalciferol and prostaglandin E2 on orthodontic tooth movement[J].Am J Orthod Dentofacial Orthop, 2004, 125(5):607-614
[10]刘长庚, 黄生高, 凌天牖, 等.中草药灯盏花对兔正畸牙移动过程中牙周组织血管内皮生长因子表达的影响[J].华西口腔医学杂志, 2006, 24(5):458-461
[11]Nishimura M, Chiba M, Ohashi T, et al.Periodontal tissue activation by vibration: intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats[J].Am J Orthod Dentofacial Orthop, 2008, 133(4):572-583
[12]Showkatbakhsh R, Jamilian A, Showkatbakhsh M.The effect of pulsed electromagnetic fields on the acceleration of tooth movement[J].World J Orthod, 2010, 11(4):e52-e56
[13]Kim DH, Park YG, Kang SG.The effects of electrical current from a microelectrical device on tooth movement[J].Korean J Orthod, 2008, 38(5):337-346
[14]Yezdani AA.Accelerated orthodontics with alveolar decortication and augmentation: a case report[J].Orthodontics, 2012, 13(1):146-155
[15]Xue H, Zheng J, Cui Z, et al.Lowintensity pulsed ultrasound accelerates tooth movement via activation of the BMP2 signaling pathway[J].PLoS One, 2013, 8(7):e68926-
[16]Jawad MM, Husein A, Alam MK, et al.Overview of noninvasive factors (low level laser and low intensity pulsed ultrasound) accelerating tooth movement during orthodontic treatment[J].Lasers Med Sci, 2014, 29(1):367-372
[17]Brudvik P, Rygh P.Root resorption after local injection of prostaglandin E2 during experimental tooth movement[J].Eur J Orthod, 1991, 13(4):255-263
[18]Karu T.Low Power Laser Therapy［M］. Boca raton: CRC Press, 2003:1-25. 
[19]Fujita S, Yamaguchi M, Utsunomiya T, et al.Lowenergy laser stimulates tooth movement velocity via expression of RANK and RANKL[J].Orthod Craniofac Res, 2008, 11(3):143-155
[20]Yamaguchi M, Fujita S, Yoshida T, et al.Lowenergy laser irradiation stimulates the tooth movement velocity via expression of MCSF and cfms[J].Orthod Waves, 2007, 66(4):139-148
[21]Yamaguchi M, Hayashi M, Fujita S, et al.Lowenergy laser irradiation facilitates the velocity of tooth movement and the expressions of matrix metalloproteinase9,cathepsin K,and alpha(v) beta(3) integrin in rats[J].Eur J Orthod, 2010, 32(2):131-139
[22]Yamaguchi M.RANKRANKLOPG during orthodontic tooth movement[J].Orthod Craniofac Res, 2009, 12(2):113-119
[23]李小彤, 张丁.正畸牙齿移动中的生物学现象[J].中华口腔正畸学杂志, 2005, 12(4):189-192
[24]Habib FA, Gama SK, Ramalho LM, et al.Effect of laser phototherapy on the hyalinization following orthodontic tooth movement in rats[J].Photomed Laser Surg, 2012, 30(3):179-185
[25]Kim SJ, Chou MY, Park YG.Effect of lowlevel laser on the rate of tooth movement[J].Seminars in Orthodontics, 2015, 21(3):210-218
[26]Huang YY, Sharma SK, Carroll J, et al.Biphasic Dose Response in Low Level Light TherapyAn Update[J].Dose Response, 2011, 9(4):602-618
[27]Lanzafame RJ, Stadler I, Kurtz AF, et al.Reciprocity of exposure time and irradiance on energy density during photoradiation on wound healing in a murine pressure ulcer model[J].Lasers Surg Med, 2007, 39(6):534-542
[28]Melis M, Di GM, Zawawi KH.Low level laser therapy for the treatment of temporomandibular disorders: a systematic review of the literature[J].Cranio, 2012, 30(4):304-312
[29]Bjordal JM, Johnson MI, Iversen V, et al.Lowlevel laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebocontrolled trials[J].Photomed Laser Surg, 2006, 24(2):158-168
[30]Altan BA, Sokucu O, Ozkut MM, et al.Metrical and histological investigation of the effects of lowlevel laser therapy on orthodontic tooth movement[J].Lasers Medical Sci, 2012, 27(1):131-140
[31]Loevschall H, ArenholtBindslev D.Effect of low level diode laser irradiation of human oral mucosa fibroblasts in vitro[J].Lasers Surg Med, 1994, 14(4):347-354
[32]Kreisler M, Christoffers AB, Willershausen B, et al.Effect of lowlevel GaAIAS laser irradiation on the proliferation rate of human periodontal ligament fibroblasts: an in vitro study[J].J Clin Periodontol, 2003, 30(4):353-358
[33]Majaron B, Srinivas SM, Huang H, et al.Deep coagulation of dermal collagen with repetitive Er:YAG laser irradiation[J].Lasers Surg Med, 2000, 26(2):215-222
[34]Karu TI, Pyatibrat LV, Kolyakov SF, et al.Absorption measurements of a cell monolayer relevant to phototherapy: reduction of cytochrome c oxidase under near IR radiation[J].Photochem Photobiol B: Biology, 2005, 81(2):98-106
[35]Chung H, Dai T, Sharma SK, et al.The nuts and bolts of lowlevel laser (light) therapy[J].Ann Biomed Eng, 2012, 40(2):516-533
[36]ElBialy T, Alhadlaq A, Felemban N, et al.The effect of lightemitting diode and laser on mandibular growth in rats[J].Angle Orthod, 2014, 85(2):233-238
[37]Greco M, Guida G, Perlino E, et al.Increase in RNA and protein synthesis by mitochondria irradiated with heliumneon laser[J].Biochem Biophys Res Commun, 1989, 163(3):1428-1434
[38]Lohr NL, Keszler A, Pratt P, et al.Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by rednear infrared radiation: potential role in cardioprotection[J].J Mol Cell Cardiol, 2009, 47(2):256-263
[39]Chen CH, Arany PR, Huang YY, et al.Lowlevel laser therapy activates NFkB via generation of reactive oxygen species in mouse embryonic fibroblasts[J].PLoS One, 2011, 6(7):e22453-
[40]Lavi R, Shainberg A, Friedmann H, et al.Low energy visible light induces reactive oxygen species generation and stimulates an increase of intracellular calcium concentration in cardiac cells[J].J Biol Chem, 2003, 278(42):40917-40922
[41]Campbell KJ, Perkins ND.Regulation of NFκB function［J］. Biochem Soc Symp, 2006, (73):165-180.
[42]Gál P, Mokr M, Vidinsk B, et al.Effect of equal daily doses achieved by different power densities of lowlevel laser therapy at 635 nm on open skin wound healing in normal and corticosteroidtreated rats[J].Lasers Medical Sci, 2009, 24(4):539-547
[43]Martius F.Das AmdtSchulz Grandgesetz［J］. Munch Med Wschr, 1923, 70: 1005-1006.
[44]Kawasaki K, Shimizu N.Effects of lowenergy laser irradiation on bone remodeling during experimental tooth movement in rats[J].Lasers Surg Med, 2000, 26(3):282-291
[45]Yoshida T, Yamaguchi M, Utsunomiya T, et al.Lowenergy laser irradiation accelerates the velocity of tooth movement via stimulation of the alveolar bone remodeling[J].Orthod Craniofac Res, 2009, 12(4):289-298
[46]Shirazi M, Akhoundi MSA, Javadi E, et al.The effects of diode laser (660 nm) on the rate of tooth movements: an animal study[J].Lasers Medical Sci, 2015, 30(2):713-718
[47]Cruz DR, Kohara EK, Ribeiro MS, et al.Effects of lowintensity laser therapy on the orthodontic movement velocity of human teeth: A preliminary study[J].Lasers Surg Med, 2004, 35(2):117-120
[48]Nimeri G, Kau CH, Corona R, et al.The effect of photobiomodulation on root resorption during orthodontic treatment［J］. Clin Cosmet Investig Dent, 2014, 6: 1-8.
[49]Youssef M, Ashkar S, Hamade E, et al.The effect of lowlevel laser therapy during orthodontic movement: a preliminary study[J].Lasers Medical Sci, 2008, 23(1):27-33
[50]Alsayed HM, Sultan K, Hamadah O.Lowlevel laser therapy effectiveness in accelerating orthodontic tooth movement: A randomized controlled clinical trial[J].Angle Orthod, 2017, 87(4):499-504
[51]Chung SE, Tompson B, Gong SG.The effect of light emitting diode phototherapy on rate of orthodontic tooth movement: a split mouth,controlled clinical trial[J].J Orthod, 2015, 42(4):274-283
[52]Dalaie K, Hamedi R, Kharazifard MJ, et al.Effect of lowlevel laser therapy on orthodontic tooth movement: A clinical investigation[J].J Dent (Tehran), 2015, 12(4):249-256
[53]Heravi F, Moradi A, Ahrari F.The effect of low level laser therapy on the rate of tooth movement and pain perception during canine retraction[J].Oral Health Dent Manag, 2014, 13(2):183-188