GBR技术引导颌骨再生的研究进展

摘要/Abstract

摘要： 引导骨再生（GBR）是修复种植体周围缺损的重要方法，但在成骨效果上仍有不足。理论上组织工程将生长因子和生物活性材料应用于GBR可以提高疗效，但是目前临床上尚未建立起可预测疗效的种植体周围缺损再生疗法，甚至有研究发现在GBR中使用生长因子后还存在成骨长期稳定性不良的现象，这与理论上预计的结果不符。解决这一问题是推进生长因子应用的关键，通过查阅文献与分析，文中给出了两种可能的原因：生长因子后期水平过低和加速屏障膜降解作用，并据此提出验证的方法，为进一步研究提供参考和依据。

关键词: 引导骨再生, 组织工程, 生长因子, 屏障膜

Abstract: Guided bone regeneration(GBR) is an important method to repair defects around the implant, but there are still deficiencies in the effect of bone formation. In theory, the application of growth factors and bioactive materials to GBR in tissue engineering can improve the efficacy. However, at present, there are no clinical predictable therapies for the regeneration of defects around the implant. Even some studies have found that the long-term stability of osteogenesis after the use of growth factors in GBR is not consistent with the theoretically expected results. This problem must be solved to advance the application of growth factors. Through literature review and analysis, two possible reasons are given in the paper: the level of growth factor is too low in later phase and the degradation of the barrier membrane is accelerated by the growth factors. Based on this, the verification method is proposed to provide reference and basis for further research.

Key words: guided bone regeneration, tissue engineering, growth factor, barrier membrane

中图分类号:

R781.4

施少杰丁锋宋应亮. GBR技术引导颌骨再生的研究进展[J]. , 2019, 39(3): 261-265.

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