牙周健康状况与男性不育症相关性的研究进展

摘要/Abstract

摘要： 口腔健康与人体全身健康密切相关。牙周病是一种发生于牙周支持组织的口腔感染性疾病，与多种全身系统性疾病存在相关性。研究表明男性不育症与口腔疾病、特别是牙周病可能存在关联。然而，其作用机制尚未明确，目前存在两种假说，其一为牙周细菌慢性感染，其二为细胞因子的作用。本文主要就牙周疾病与男性不育症相关性及其可能作用机制进行综述。

关键词: 牙周病, 慢性感染, 不育症, 精子质量

Abstract: Oral health is closely related to general health. Periodontal disease, an oral infectious disease occurring at periodontal tissues, might be related to some systemic diseases. Some studies show that male infertility might be related to some oral diseases, especially to periodontal diseases. However, its mechanism of action remains uncertain and there are two hypotheses supporting this association，namely，the chronic infection of periodontal bacteria and the effect of cytokines. This article aims to review the association between periodontal condition and male infertility and the possible mechanism of the action.

Key words: Periodontal disease, Chronic Inflammation, Infertility, Semen Quality

中图分类号:

R781.4

朱佳琳冯希平陶丹英. 牙周健康状况与男性不育症相关性的研究进展[J]. , 2019, 39(8): 762-764.

参考文献 38

[1]	Qi XQ.The third national oral health epidemiological survey report[J].Beijing: People’s Medical Publishing House, 2008, :82-83
[2]	Cardona Maya W.Current definition and treatment of premature ejaculation[J].Arch Esp Urol, 2010, 63(1):53-55
[3]	孙志涛, 孙阳, 宋宇.牙周病引起冠心病的临床相关性综述[J].现代口腔医学杂志, 2017, 31(03):176-179
[4]	ORLANDI M, SUVAN J, PETRIE A, et al.Association between periodontal disease and its treatment,flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis[J].Atherosclerosis, 2014, 236(1):39-46
[5]	Mesia Ruben, Gholami Fatemeh, Huang Hong, et al.Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis[J].BMJ Open Diab Res Care, 2016, 4(1):e000260-e000260
[6]	任婉峰.类风湿性关节炎患者牙槽骨吸收程度的临床探讨[J].全科口腔医学电子杂志, 2016, 3(12):74-75
[7]	Chen HH，Huang N，Chen Y，et al.Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide， population-based，ease-control study[J].Ann Ｒheum Dis, 2013, 72(7):1206-1211
[8]	Richa, R Y, Puranik M P, et al.Association between osteoporosis and periodontal disease among postmenopausal Indian women [J].Journal of Investigative & Clinical Dentistry, 2006, 8(3):-
[9]	Kavoussi S K, West B T, Taylor G W, et al.Periodontal disease and endometriosis: Analysis of the National Health and Nutrition Examination Survey[J].Fertility & Sterility, 2009, 91(2):335-342
[10]	Meqa K, Dragidella F, Disha M, et al.The Association between Periodontal Disease and Preterm Low Birthweight in Kosovo [J].Acta Stomatologica Croatica, 2017, (1):33-40
[11]	Puertas A, Maganfernandez A, Blanc V, et al.Association of periodontitis with preterm birth and low birth weight: a comprehensive review [J].The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2017, 31(5):1-6
[12]	Teshome A, Yitayeh A.Relationship between periodontal disease and preterm low birth weight: systematic review[J].Pan African Medical Journal, 2016, 24:215-215
[13]	车洋洋, 郭艳巍, 毛淑芳.孕妇牙周病与低出生体重儿关系的流行病学研究进展[J].中国妇幼保健, 2016, 31(16):3412-3414
[14]	Virtanen E, Nurmi T, S?der P ?, et al.Apical periodontitis associates with cardiovascular diseases: a cross-sectional study from Sweden[J].Bmc Oral Health, 2017, 17(1):107-
[15]	Teeuw WJ, Slot DE, Susanto H, et al.Treatment of periodontitis improves the atherosclerotic profile: a systematic review and metaanalysis[J].J Clin Periodontol, 2014, 41(1):70-9
[16]	Craig Niederberger, Craig Niederberger.WHO manual for the standardized investigation,diagnosis and management of the infertile male[J].Urology, 2001, 57(1):208-208
[17]	张颖, 李青, 单伟颖.男性不育症相关因素研究进展[J].承德医学院学报, 2015, (1):57-59
[18]	Klinger A, Hain B, Yaffe H, et al.Periodontal status of males attending an in vitro fertilization clinic[J].Journal of Clinical Periodontology, 2011, 38(6):542-546
[19]	Nwhator S O, Umeizudike K A, Ayanbadejo P O, et al.Another reason for impeccable oral hygiene: oral hygiene-sperm count link[J].J Contemp Dent Pract, 2014, 15(3):352-358
[20]	Zhu C, Qin Z, Huang H, et al.The correlation study between male infertility and chronic periodontitis[J].China Modern Medicine, 2010, :-
[21]	Práger N, Pásztor N, Várnagy á, et al.Idiopathic male infertility related to periodontal and caries status[J].Journal of Clinical Periodontology, 2017, 44(9):-
[22]	Pásztor N, Kárpáti K, Sz?ll?si J, et al.Association between periodontal status and idiopathic male infertility[J].Journal of Oral Science, 2016, 58(2):247-
[23]	赵妍, 于阳, 寇育荣.牙龈卟啉单胞菌调控细胞自噬的分子机制研究进展[J].华西口腔医学杂志, 2017, 35(6):654-658
[24]	Dibary J.Periodontitis and Cardiovascular Disease[J].Disease-a-Month, 2011, 57(4):203-205
[25]	Hajishengallis G.Periodontitis : from microbial immune sub-version to systemic inflammation[J].Nature Reviews Immunology, 2015, 15(1):30-4
[26]	Linossier A, Thumann A, Bustos‐Obregon E.Sperm immobilization by dental focus microorganisms[J].Andrologia, 1982, 14(3):250-255
[27]	Paulson J D, Leto S.The reproductive effects of microorganisms in semen[J]., 1985, :-
[28]	Riedel H H, Langenbucher H, Mettler L.Significance of sperm bacteriology for the in vitro fertilization of human and mouse oocytes[J].Journal of Reproductive Medicine, 1986, 31(7):605-8
[29]	Bieniek K W, Riedel H.HBacterial foci in the teeth,oral cavity,and jaw--secondary effects (remote action) of bacterial colonies with respect to bacteriospermia and subfertility in males.[J].Andrologia, 1993, 25(3):159-
[30]	Gokhale S.Periodontal disease and overall health: An update[J].European Journal of General Dentistry, 2013, 2(2):102-108
[31]	Akira S, Takeda K.Toll-like receptor signaling[J].Nat Rev Immunol, 2004, 4(7):499-511
[32]	李芳芳, 武云霞.炎症性口腔疾病与胰岛素抵抗的相关研究进展[J].中华临床医师杂志:电子版, 2016, 10(22):3459-3462
[33]	Andrukhov O, Ulm C, Reischl H, et al.Serum cytokine levels in periodontitis patients in relation to the bacterial load[J].Journal of Periodontology, 2011, 82(6):885-92
[34]	Nwhator S O, Umeizudike K A, Ayanbadejo P O, et al.Another reason for impeccable oral hygiene: oral hygiene-sperm count link[J].J Contemp Dent Pract, 2014, 15(3):352-358
[35]	李怀平, 梁丽平, 阎妍.慢性牙周炎患者血清及龈沟液中炎性细胞因子的变化观察 [J].疑难病杂志, 2014, (12):1297-1299
[36]	Camejo M I, Segnini A, Proverbio F.Interleukin-6 (IL-6) in seminal plasma of infertile men,and lipid peroxidation of their sperm[J].Archives of Andrology, 2001, 47(2):97-101
[37]	Maeda H, Miyamoto M, Hongyo H, et al.Heat shock protein 60 (GroEL) from Porphyromonas gingivalis: Molecular cloning and sequence analysis of its gene and purification of the recombinant protein[J].Fems Microbiology Letters, 1994, 124(1):121-122
[38]	Eggertkruse W, Neuer A, Clussmann C, et al.Seminal antibodies to human 60kd heat shock protein (HSP 60) in male partners of subfertile couples[J].Human Reproduction, 2002, 17(3):726-