间充质干细胞来源的脱细胞基质及其研究进展

摘要/Abstract

摘要： 干细胞一直是国内外医学研究的热点，尤其在再生医学领域。间充质干细胞作为应用较广泛的干细胞，通过近年来的研究，其分泌的细胞外基质已经可以被有效获取，它对细胞的增殖、生长以及定向分化有相应的促进作用，具有供体来源丰富、可防止病原传染、减少自身免疫反应等优势，是组织工程学研究的理想生物材料。本文就间充质干细胞来源的脱细胞基质的概念、成分、获取方法、研究进展及应用前景作一综述。

关键词: 间充质干细胞, 细胞外基质, 组织工程, 骨再生

Abstract: Stem cells have been a hotspot of medical research at home and abroad, especially in the field of regenerative medicine. As one of the most widely used stem cells, mesenchymal stem cell derived extracellular matrix（MSC-ECM） has been successfully isolated and proved to be effective in cell proliferation, development and orientated differentiation and so on through recent research. Furthermore, because of its rich resources, preventing pathogen transmission and reducing autoimmunity, MSC-ECM is considered to be an ideal biological material for tissue engineering. This comprehensive review mainly focused on concept, ingredient, the acquisition methods, research progress and application prospect of mesenchymal stem cell-derived extracellular matrix.

Key words: Mesenchymal stem cell, Extracellular matrix, Tissue engineering, Bone regeneration

中图分类号:

R329.28

冯煜婷姜治伟杨国利谢志坚. 间充质干细胞来源的脱细胞基质及其研究进展[J]. 口腔医学, 2020, 40(3): 271-274.

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