磁性纳米材料在口腔疾病诊治中的应用

摘要/Abstract

摘要： 磁性纳米材料具有多种优良性能，是目前生物医学领域的研究热点之一。目前磁性纳米材料已经在一些口腔常见疾病的诊治中开展研究，主要包括了：基于磁性纳米材料的电化学免疫方法应用于口腔黏膜病的早期诊断；磁性纳米材料加入纤维支架材料，诱导口腔细胞定向分化应用于骨及牙再生研究；磁性纳米颗粒改性的抗菌牙科材料防治口腔感染性疾病。本文回顾了近年来磁性纳米材料应用于常见口腔疾病诊治的研究进展。

关键词: 磁性纳米材料, 口腔黏膜病, 口腔再生医学, 抗菌牙科材料

Abstract: Magnetic nanomaterials have a variety of excellent properties, making it a research hotspot in the field of biomedicine. At present, magnetic nanomaterials have been studied in the diagnosis and treatment of some common oral diseases, including the early diagnosis of oral mucosal disease realized by electrochemical immunization based on magnetic nanomaterials；magnetic nanomaterials added to fiber scaffolds to induce directional differentiation of oral cells so as to achieve bone and tooth regeneration；magnetic nanoparticles used to prevent and cure oral infectious diseases by modifying antibacterial dental materials. This paper reviews the recent progress of magnetic nanomaterials in the diagnosis and treatment of common oral diseases.

Key words: Magnetic nanomaterials, Oral mucosal disease, Oral Regenerative Medicine, Antibacterial dental materials

陈燕茹李明云程磊. 磁性纳米材料在口腔疾病诊治中的应用[J]. 口腔医学, 2021, 41(8): 732-736.

参考文献 48

[1]	Karimi Z, Karimi L, Shokrollahi H. Nano-magnetic particles used in biomedicine: core and coating materials[J]. Mater Sci Eng C Mater Biol Appl,2013,33(5):2465-2475.
[2]	Li X, Wei J, Aifantis KE, et al. Current investigations into magnetic nanoparticles for biomedical applications[J]. J Biomed Mater Res A,2016,104(5):1285-1296.
[3]	Hou YH, Wang JJ, Jiang YZ, et al. A colorimetric and electrochemical immunosensor for point-of-care detection of enterovirus 71[J].Biosens Bioelectron,2018,99:186-192.
[4]	Yun HM, Lee ES, Kim MJ, et al. Magnetic Nanocomposite Scaffold-Induced Stimulation of Migration and Odontogenesis of Human Dental Pulp Cells through Integrin Signaling Pathways[J].PLoS One,2015,10(9):e0138614.
[5]	Bocanegra Gondan AI, Ruiz-de-Angulo A, Zabaleta A, et al. Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles[J]. Biomaterials, 2018,170:95-115.
[6]	Maldonado-Camargo L, Unni M, Rinaldi C. Magnetic Characterization of Iron Oxide Nanoparticles for Biomedical Applications[J]. Methods Mol Biol, 2017, 1570: 47-71.
[7]	Ma Y, Chen T, Iqbal MZ, et al. Applications of magnetic materials separation in biological nanomedicine[J]. Electrophoresis,2019,40(16-17):2011-2028.
[8]	Chandrasekharan P, Tay ZW, Hensley D, et al. Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications[J]. Theranostics,2020,10(7):2965-2981.
[9]	Hu S, Zhou Y, Zhao Y, et al. Enhanced bone regeneration and visual monitoring via superparamagnetic iron oxide nanoparticle scaffold in rats[J].J Tissue Eng Regen Med,2018,12(4):e2085-e2098.
[10]	Wang LQ, Lu XG, Wang JQ, et al. Facile synthesis of Fe@Fe2O3, nanochains exhibiting high heating efficiency in magnetic hyperthermia[J]. J Alloys Compd, 2016, 681(5): 50-56.
[11]	Gao L, Zhuang J, Nie L, et al. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles[J].Nat Nanotechnol,2007,2(9):577-583.
[12]	Wu J, Wang X, Wang Q, et al. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)[J]. Chem Soc Rev,2019,48(4):1004-1076.
[13]	Ajkidkarn P, Ritprajak P, Injumpa W, et al. Synthesis, characterization, drug release and transdentinal delivery studies of magnetic nanocubes coated with biodegradable poly(2-(dimethyl amino)ethyl methacrylate)[J].J Magn Magn Mater,2017,427:235-240.
[14]	Wu K, Su D, Liu J,et al. Magnetic nanoparticles in nanomedicine: a review of recent advances[J]. Nanotechnology,2019,30(50):502003.
[15]	Balavijayalakshmi J, Suriyanarayanan N, Jayaprakash R. Effects of sinteringon structural and magnetic properties of Cu substituted cobalt- nickel mixed ferrite nanoparticles[J]. J Magnet Magnet Mater,2014,362:135–140.
[16]	Sun S, Zhong B, Li W, et al. Immunological methods for the diagnosis of oral mucosal diseases[J]. Br J Dermatol,2019,181(1):23-36.
[17]	Jampasa S, Lae-Ngee P, Patarakul K, et al. Electrochemical immunosensor based on gold-labeled monoclonal anti-LipL32 for leptospirosis diagnosis[J]. Biosens Bioelectron,2019,142:111539.
[18]	Sobczak-Kupiec A, Venkatesan J, Alhathal AlAnezi A, et al. Magnetic nanomaterials and sensors for biological detection[J]. Nanomedicine,2016,12(8):2459-2473.
[19]	Krause CE, Otieno BA, Bishop GW, et al. Ultrasensitive microfluidic array for serum pro-inflammatory cytokines and C-reactive protein to assess oral mucositis risk in cancer patients[J].Anal Bioanal Chem,2015,407(23):7239-7243.
[20]	Shanavas A, Sasidharan S, Bahadur D, et al. Magnetic core-shell hybrid nanoparticles for receptor targeted anti-cancer therapy and magnetic resonance imaging[J]. J Colloid Interface Sci,2017,486:112-120.
[21]	Yang Y, Zhou B, Zhou J, et al. Assessment of lingual sentinel lymph nodes metastases using dual-modal indirect CT/MR lymphography with gold-gadolinium-based nanoprobes in a tongue VX2 carcinoma model[J]. Acta Otolaryngol,2018,138(8):727-733.
[22]	Zhang Y, Yang H, Zhou Z, et al. Recent Advances on Magnetic Relaxation Switching Assay-Based Nanosensors[J]. Bioconjug Chem,2017,28(4):869-879.
[23]	Perez JM, Simeone FJ, Saeki Y, et al. Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media[J]. J Am Chem Soc,2003,125(34):10192-10193.
[24]	Meng J, Zhang Y, Qi X, et al. Paramagnetic nanofibrous composite films enhance the osteogenic responses of pre-osteoblast cells[J].Nanoscale,2010,2(12):2565-2569.
[25]	Yun HM, Ahn SJ, Park KR, et al. Magnetic nanocomposite scaffolds combined with static magnetic field in the stimulation of osteoblastic differentiation and bone formation[J].Biomaterials,2016,85:88-98.
[26]	Xia Y, Guo Y, Yang Z, et al. Iron oxide nanoparticle-calcium phosphate cement enhanced the osteogenic activities of stem cells through WNT/beta-catenin signaling[J].Mater Sci Eng C Mater Biol Appl,2019,104:109955.
[27]	Xia Y, Chen H, Zhao Y, et al. Novel magnetic calcium phosphate-stem cell construct with magnetic field enhances osteogenic differentiation and bone tissue engineering[J].Mater Sci Eng C Mater Biol Appl,2019,98:30-41.
[28]	Yun HM, Kang SK, Singh RK, et al. Magnetic nanofiber scaffold-induced stimulation of odontogenesis and pro-angiogenesis of human dental pulp cells through Wnt/MAPK/NF-κB pathways[J]. Dent Mater,2016,32(11):1301-1311.
[29]	Koto W, Shinohara Y, Kitamura K, et al. Porcine Dental Epithelial Cells Differentiated in a Cell Sheet Constructed by Magnetic Nanotechnology[J].Nanomaterials(Basel),2017,7（10）:322.
[30]	Jegal SH, Park JH, Kim JH, et al. Functional composite nanofibers of poly(lactide-co-caprolactone) containing gelatin-apatite bone mimetic precipitate for bone regeneration[J]. Acta Biomater,2011,7(4):1609-1617.
[31]	Sasaki T, Iwasaki N, Kohno K, et al. Magnetic nanoparticles for improving cell invasion in tissue engineering[J]. J Biomed Mater Res A,2008,86(4):969-978.
[32]	Cicha I, Lyer S, Janko C, et al. Magnetic nanoparticles for medical applications[J] .Nanomedicine (Lond), 2017, 12: 825-829.
[33]	Verma D, Garg PK, Dubey AK. Insights into the human oral microbiome[J]. Arch Microbiol,2018,200(4):525-540.
[34]	孟焕新.2018年牙周病和植体周病国际新分类简介 [J].中华口腔医学杂志,2019,54（2）:73-78. Meng HX. 2018 world new classification of periodontal and peri-implant diseases and conditions[J]. Chinese Journal of Stomatology, 2019,54(2):73-78.
[35]	Krishnan K, Chen T, Paster BJ. A practical guide to the oral microbiome and its relation to health and disease[J]. Oral Dis,2017,23(3):276-286.
[36]	Rodrigues GR, Lopez-Abarrategui C, de la Serna Gomez I, et al. Antimicrobial magnetic nanoparticles based-therapies for controlling infectious diseases[J]. Int J Pharm,2019,555:356-367.
[37]	Mahmoudi M, Serpooshan V. Silver-coated engineered magnetic nanoparticles are promising for the success in the fight against antibacterial resistance threat[J].ACS Nano,2012,6(3):2656-2664.
[38]	Thukkaram M, Sitaram S, Kannaiyan SK, et al. Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces[J].Int J Biomater,2014,2014:716080.
[39]	Gao L, Liu Y, Kim D, et al. Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo[J].Biomaterials,2016,101:272-284.
[40]	Horev B, Klein MI, Hwang G, et al. pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence[J].ACS Nano,2015,9(3):2390-2404.
[41]	Sun X, Wang L, Lynch CD, et al. Nanoparticles having amphiphilic silane containing Chlorin e6 with strong anti-biofilm activity against periodontitis-related pathogens[J]. J Dent,2019,81:70-84.
[42]	Ji H, Dong K, Yan Z, et al. Bacterial Hyaluronidase Self-Triggered Prodrug Release for Chemo-Photothermal Synergistic Treatment of Bacterial Infection[J].Small,2016,12(45):6200-6206.
[43]	Gao L, Giglio KM, Nelson JL, et al. Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination[J].Nanoscale,2014,6(5):2588-2593.
[44]	Hwang G, Paula AJ, Hunter EE, et al. Catalytic antimicrobial robots for biofilm eradication[J].Sci Robot,2019,4(29):eaaw2388.
[45]	Ji Y, Choi SK, Sultan AS, et al. Nanomagnetic-mediated drug delivery for the treatment of dental disease[J].Nanomedicine,2018,14(3):919-927.
[46]	Niemirowicz-Laskowska K, Mystkowska J, ?ysik D, et al. Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles[J]. Int J Mol Sci,2020,21(6):1979.
[47]	Luo D, Shahid S, Hasan SM, et al. Controlled release of chlorhexidine from a HEMA-UDMA resin using a magnetic field[J].Dent Mater,2018,34(5):764-775.
[48]	Pappus SA, Mishra M. A Drosophila Model to Decipher the Toxicity of Nanoparticles Taken Through Oral Routes[J]. Adv Exp Med Biol,2018,1048:311-322.