关键词: 碱性成纤维细胞生长因子, 轻型复发性口腔溃疡, Meta分析, basic fibroblast growth factor, light Recurrent aphthous ulcers, meta analysis

Abstract: Objective Evaluate the curative effects of basic fibroblast growth factor in treatment of light recurrent aphthous ulcers.Methods The randomized controlled trials (RCTs) were retrieved about the basic fibroblast growth factor in treatment of light recurrent aphthous ulcers from PubMed,CENTRAL,EMbase,CNKI and WANFANG from January 1,1989 to March 1,2012,and at the same time,the references included in the study were manually selected.After quality evaluation and material extraction by the reviewer,Meta analysis was done to the documents and materials by using software RevMan 5.0.Results 5 RCTs involving 425 patients were included in the study,with 218 cases in the treatment group (using basic fibroblast growth factor) and 207 cases in the control group (using metronidazole,chlorhexidine dexamethasone,and vitamin B).Meta analysis results showed that the pain index,the healing time of the treatment group and recurrent frequency of patients with recurrent light recurrent aphthous ulcers in the treatment group were all better than those in the control group.There was significant difference（P<0.05）.Conclusions Compared with traditional treatment programs,basic fibroblast growth factor can significantly enhance the efficacy of treating light recurrent aphthous ulcers in patients.