钛片阻断下颌骨单侧骨断面的牵张成骨的实验研究

›› 2014, Vol. 34 ›› Issue (7): 497-499.

钛片阻断下颌骨单侧骨断面的牵张成骨的实验研究

杨学明¹,马露²,王东苗³,浦丽飞⁴,储伟明¹,宋晓萌⁵,李刚²,吴煜农²

1. 南京医科大学附属江苏省口腔医院,南京医科大学口腔医学研究所
2. 南京医科大学附属江苏省口腔医院
3. 南京医科大学附属口腔医院口腔颌面外科
4. 江苏省口腔医院
5. 南京医科大学口腔医学院

收稿日期:2013-12-02 修回日期:2014-02-08 出版日期:2014-07-28 发布日期:2014-08-04
通讯作者: 吴煜农 E-mail:wynoms@gmail.com
基金资助:
江苏省卫生厅医学科研项目;江苏省优势学科

Experimental study of mandibular distraction osteogenesis with titanium membrane as the transition disc

Received:2013-12-02 Revised:2014-02-08 Online:2014-07-28 Published:2014-08-04
Contact: Yu-Nong Wu E-mail:wynoms@gmail.com

摘要/Abstract

摘要： 目的　研究钛片阻断下颌骨单侧骨断面的牵张成骨。方法　新西兰白兔10只，行单侧下颌骨截开，用钛膜覆盖一侧切开端整个骨面，延迟5 d，以每天0.8 mm、每天2次牵引8 mm，固定16周，分别行大体、放射学和组织学观察。结果　3只完成牵张，2只钛片与骨断端间有部分新骨形成。结论　钛作为有可能的输送盘还需进一步研究。

关键词: 钛, 牵张成骨, 兔

Abstract: 　Objective　To investigate whether titanium material could be used as transition disc during distraction osteogenesis. Methods　Unilateral mandible split was performed in 10 New Zealand white rabbits. Titanium membrane was inserted into the fracture site and covered one side surface. After 5 days’ delay, distraction was performed 0.8mm per day and twice a day. Total distraction length was 8 mm. After 16 weeks’fixation，the new bones were grafted and subjected to histological radiologic and pathological analysis. Results　Successful distractions were found in 3 of the rabbits. Some new bone formation could be detected in 2 of the rabbits. Conclusion　Titanium material might be used as the transition disc during osteogenesis distraction.

Key words: Titanium, Distraction Osteogenesis, Rabbit

中图分类号:

R782.23

杨学明马露王东苗浦丽飞储伟明宋晓萌李刚吴煜农. 钛片阻断下颌骨单侧骨断面的牵张成骨的实验研究[J]. 口腔医学, 2014, 34(7): 497-499.

参考文献

[1]McCarthy JG,Schreiber J,Karp N,et al.Lengthening the human mandible by gradual distraction[J].Plast Reconstr Surg,1992,89(1):1-8
[2]Neelakandan RS,Bhargava D.Transport distraction osteogenesis for maxillomandibular reconstruction: current concepts and applications[J].J Maxillofac Oral Surg,2012,11(3):291-299
[3]李刚,宋晓萌,高兴亚,等.变速牵引成骨对兔下牙槽神经的影响[J].口腔医学,2005,25(2):93-95
[4]Zapata U,Elsalanty ME,Dechow PC,et al.Biomechanical configurations of mandibular transport distraction osteogenesis devices[J].T3 Eng Part B Rev,2010,16(3):273-283
[5]Ilizarov GA.The tension-stress effect on the genesis and growth of ts: Part IIThe influence of the rate and frequency of distraction[J].. Clin Orthop Relat Res,1989,239):263-285
[6]Ai-Aql ZS,Alagl AS,Graves DT,,et al.Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis[J].J Dent Res,2008,87(2):107-118
[7]Sacco AG,Chepeha DB.Current status of transport-disc-distraction osteogenesis for mandibular reconstruction[J].Lancet Oncol,2007,8(4):323-330
[8]Kuriakose MA,Shnayder Y,DeLacure MD.Reconstruction of segmental mandibular defects by distraction osteogenesis for mandibular reconstruction[J].Head Neck,2003,25(10):816-824
[9]Zhou L,Shang H,Feng Z,et al.Segmental curvilinear distraction osteogenesis[J].Med Hypotheses,2012,79(4):427-429
[10]Fukuda M,Iino M,Yamaoka K,Ohnuki T,et al.Two-stage distraction osteogenesis for mandibular segmental defect[J].J Oral Maxillofac Surg,2004,62(9):1164-1168
[11]Kramer FJ,Mueller M,Rahmstorf M,et al.Ortho- and heterotopic bone grafts in bifocal transport osteogenesis for craniofacial reconstruction--an experimental study in sheep[J].Int J Oral Maxillofac Surg,2004,33(6):575-83
[12]Kramer FJ,Sinikovic B,Mueller M,et al.Experimental application of a biomaterial in bifocal transport osteogenesis for craniofacial reconstruction[J].J Craniomaxillofac Surg,2008,36(4):218-226
[13]Watanabe K,Tsuchiya H,Sakurakichi K,et al.Bone transport using hydroxyapatite loaded with bone morphogenetic protein in rabbits[J].J Bone Joint Surg Br,2007,89(8):1122-1129
[14]Yamauchi K,Takahashi T,Funaki K,et al.Periosteal expansion osteogenesis using highly purified beta-tricalcium phosphate blocks: a pilot study in dogs[J].J Periodontol,2008,79(6):999-1005
[15]Karahalil B,Kadioglu E,Tuzuner-Oncul AM,et al.Micronucleus assay assessment of possible genotoxic effects in patients treated with titanium alloy endosseous implants or miniplates[J].Mutat Res,2014,760:70-72
[16]Ghaffari M,Moztarzadeh F,Sepahvandi A,et al.How bone marrow-derived human mesenchymal stem cells respond to poorly crystalline apatite coated orthopaedic and dental titanium implants[J].Ceramics International,2013,39(7):7793-7802