抗菌肽在牙本质粘接剂中应用的研究进展

doi:10.13591/j.cnki.kqyx.2022.02.012

摘要/Abstract

摘要： 近几十年,牙本质粘接剂历经多代改良趋向多功能化和操作简便化,并在口腔修复治疗中广泛应用。为获得理想的远期修复效果,牙本质粘接剂在具备良好的物理化学和机械性能基础上,还需具备有效的抗龋性能。该文将重点从抗菌肽的抗菌作用机制、抗菌肽的种类、在牙本质粘接剂中的应用及防龋效果等方面展开综述,并对抗菌肽在牙本质粘接剂应用中面临的挑战和发展前景作出展望。

关键词: 牙本质粘接剂, 抗菌肽, 抗菌性能, 粘接耐久性

Abstract: In recent decades, dentin adhesives have undergone many generations of improvements and tend to be multi-functional and easy to operate, and are widely used in oral prosthetic treatment. In order to obtain an ideal long-term restoration effect, in addition to good physical, chemical and mechanical properties of dentin adhesives, effective anti-caries properties are also key factors that need to be considered. This paper will focus on the antimicrobial mechanism of antimicrobial peptides, the types of antimicrobial peptides, their application in dentin adhesives and their anti-caries effect. Challenges and prospects for the application of antimicrobial peptides in dentin adhesives are also discussed.

Key words: dentin adhesive, antimicrobial peptide, antimicrobial property, bonding durability

中图分类号:

R783.1

冯杉杉, 金毅夫, 陈欢, 侯妍妍, 丁景瑜, 朱松. 抗菌肽在牙本质粘接剂中应用的研究进展[J]. 口腔医学, 2022, 42(2): 156-159.

FENG Shanshan, JIN Yifu, CHEN Huan, HOU Yanyan, DING Jingyu, ZHU Song. Research progress on the application of antimicrobial peptides in dentin adhesives[J]. Stomatology, 2022, 42(2): 156-159.

参考文献

[1] Tjäderhane L. Dentin bonding:Can we make it last?[J]. Oper Dent, 2015, 40(1):4-18.
[2] Tjäderhane L, Nascimento FD, Breschi L, et al. Strategies to prevent hydrolytic degradation of the hybrid layer-A review[J]. Dent Mater, 2013, 29(10):999-1011.
[3] Yi L, Yu J, Han L,et al. Combination of baicalein and ethanol-wet-bonding improves dentin bonding durability[J]. J Dent, 2019, 90:103207.
[4] Simmer FS, da Silva EM,Bezerra RDSG, et al. Bond stability of conventional adhesive system with MMP inhibitors to superficial and deep dentin[J]. J Mech Behav Biomed Mater, 2019, 100:103402.
[5] WangJJ, Dou XJ, Song J, et al. Antimicrobial peptides:Promising alternatives in the post feeding antibiotic era[J]. Med Res Rev, 2019, 39(3):831-859.
[6] Marsh PD. Controlling the oral biofilm with antimicrobials[J]. J Dent, 2010,38(Suppl 1):S11-S15.
[7] Chen C, Cheng L, Weir MD,et al. Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks[J]. Int J Oral Sci, 2016, 8(4):239-245.
[8] Paula AB, Alonso RCB,Taparelli JR, et al. Influence of the incorporation of triclosan methacrylate on the physical properties and antibacterial activity of resin composite[J]. J Appl Oral Sci, 2019, 27:e20180262. DOI:10.1590/1678-7757-2018-0262.
[9] Marsh PD, Head DA, Devine DA. Ecological approaches to oral biofilms:Control without killing[J]. Caries Res, 2015, 49(Suppl 1):46-54.
[10] Sullivan R,Santarpia P, Lavender S, et al. Clinical efficacy of a specifically targeted antimicrobial peptide mouth rinse:Targeted elimination of Streptococcus mutans and prevention of demineralization[J]. Caries Res, 2011, 45(5):415-428.
[11] Melo MN,Ferre R, Castanho MA. Antimicrobial peptides:Linking partition, activity and high membrane-bound concentrations[J]. Nat Rev Microbiol, 2009, 7(3):245-250.
[12] Boparai JK, Sharma PK. Minireview on antimicrobial peptides, sources, mechanism and recent applications[J]. Protein Pept Lett, 2020, 27(1):4-16.
[13] Epand RM, Walker C, Epand RF, et al. Molecular mechanisms of membrane targeting antibiotics[J]. Biochim Biophys Acta, 2016, 1858(5):980-987.
[14] Andersson DI, Hughes D,Kubicek-Sutherland JZ. Mechanisms and consequences of bacterial resistance to antimicrobial peptides[J]. Drug Resist Updat, 2016, 26:43-57.
[15] Nguyen LT, Haney EF, Vogel HJ. The expanding scope of antimicrobial peptide structures and their modes of action[J]. TrendsBiotechnol, 2011, 29(9):464-472.
[16] Kreling PF, Aida KL, Massunari L, et al. Cytotoxicity and the effect of cationic peptide fragments against cariogenic bacteria under planktonic and biofilm conditions[J]. Biofouling, 2016, 32(9):995-1006.
[17] Kõll-Klais P, Mändar R, Leibur E, et al. Oral lactobacilli in chronic periodontitis and periodontal health:Species composition and antimicrobial activity[J]. Oral Microbiol Immunol, 2005, 20(6):354-361.
[18] Liang DS, Li HY, Xu XH, et al. Rational design of peptides with enhanced antimicrobial and anti-biofilm activities against cariogenic bacterium Streptococcus mutans[J]. Chem Biol Drug Des, 2019, 94(4):1768-1781.
[19] Liang JH, Liang DS, Liang YE, et al. Effects of a derivative of reutericin 6 and gassericin A on the biofilm of Streptococcus mutans in vitro and caries prevention in vivo[J]. Odontology, 2021, 109(1):53-66.
[20] Deslouches B, Phadke SM, Lazarevic V, et al. De novo generation of cationic antimicrobial peptides:Influence of length and tryptophan substitution on antimicrobial activity[J]. Antimicrob Agents Chemother, 2005, 49(1):316-322.
[21] Kaplan CW, Sim JH, Shah KR,et al. Selective membrane disruption:Mode of action of C16G2, a specifically targeted antimicrobial peptide[J]. Antimicrob Agents Chemother, 2011, 55(7):3446-3452.
[22] Jiang WT, Wang YF, Luo JY, et al. Antimicrobial peptide GH12 prevents dental caries by regulating dental plaque microbiota[J]. Appl Environ Microbiol, 2020, 86(14):e00527-e00520.
[23] Li L, He J, Eckert R, et al. Design and characterization of an acid-activated antimicrobial peptide[J]. Chem Biol Drug Des, 2010, 75(1):127-132.
[24] Jiang W, Luo J, Wang Y, et al. The pH-responsive property of antimicrobial peptide GH12 enhances its anticaries effects at acidic pH[J]. Caries Res, 2021, 55(1):21-31.
[25] Kashiwada A, Mizuno M, Hashimoto J. pH-Dependent membrane Lysis by using melittin-inspired designed peptides[J]. Org Biomol Chem, 2016, 14(26):6281-6288.
[26] Wang Y, Fan Y, Zhou Z, et al. De novo synthetic short antimicrobial peptides against cariogenic bacteria[J]. Arch Oral Biol, 2017, 80:41-50.
[27] Jiang WT, Wang YF, Luo JY, et al. Effects of antimicrobial peptide GH12 on the cariogenic properties and composition of a cariogenic multispecies biofilm[J]. Appl Environ Microbiol, 2018, 84(24):e01423-e01418.
[28] Xie SX, Song L, Yuca E, et al. Antimicrobial peptide-polymer conjugates for dentistry[J]. ACS Appl Polym Mater, 2020, 2(3):1134-1144.
[29] Xie SX, Boone K, VanOosten SK, et al. Peptide mediated antimicrobial dental adhesive system[J]. Appl Sci (Basel), 2019, 9(3):557.
[30] Wisdom C, VanOosten SK, Boone KW, et al. Controlling the biomimetic implant interface:Modulating antimicrobial activity by spacer design[J]. J Mol Eng Mater, 2016, 4(1):1640005.
[31] Wisdom EC, Zhou Y, Chen C, et al. Mitigation of peri-implantitis by rational design of bifunctional peptides with antimicrobial properties[J]. ACS Biomater Sci Eng, 2020, 6(5):2682-2695.
[32] Song LY, Ge XP, Ye Q, et al. Modulating pH through lysine integrated dental adhesives[J]. Dent Mater, 2018, 34(11):1652-1660.
[33] Yi X, He JP, Wang XL, et al. Tunable mechanical, antibacteri-al, and cytocompatible hydrogels based on a functionalized dual network of metal coordination bonds and covalent crosslinking[J]. ACS Appl Mater Interfaces, 2018, 10(7):6190-6198.
[34] Tong ZC, Dong LP, Zhou L, et al. Nisin inhibits dental caries-associated microorganism in vitro[J]. Peptides, 2010, 31(11):2003-2008.
[35] Cerrutti P, Terebiznik MR, de Huergo MS, et al. Combined effect of water activity and pH on the inhibition of Escherichia coli by nisin[J]. J Food Prot, 2001, 64(10):1510-1514.
[36] Su MX, Yao SY, Gu LS, et al. Antibacterial effect and bond strength of a modified dental adhesive containing the peptide nisin[J]. Peptides, 2018, 99:189-194.
[37] Zhao M, Qu Y, Liu J, et al. A universal adhesive incorporating antimicrobial peptide nisin:effects on Streptococcus mutans and saliva-derived multispecies biofilms[J].Odontology, 2020,108(3):376-385.
[38] Ye Q, Spencer P, Yuca E, et al. Engineered peptide repairs defective adhesive-dentin interface[J].Macromol Mater Eng,2017,302(5):1600487.
[39] Zhou C, Zhang D, Bai Y, et al. Casein phosphopeptide-amorphous calcium phosphate remineralization of primary teeth early enamel lesions[J].J Dent,2014,42(1):21-29.
[40] Chen F, Jia ZS, Rice KC, et al. The development of dentotropic micelles with biodegradable tooth-binding moieties[J]. Pharm Res, 2013, 30(11):2808-2817.
[41] Zhou L, Wong HM, Zhang YY, et al. Constructing an antibiofouling and mineralizing bioactive tooth surface to protect against decay and promote self-healing[J]. ACS Appl Mater Interfaces, 2020, 12(2):3021-3031.
[42] Sarikaya R, Song LY, Yuca E, et al. Bioinspired multifunctional adhesive system for next generation bio-additively designed dental restorations[J]. J Mech Behav Biomed Mater, 2021, 113:104135.
[43] Song LY, Ye Q, Ge XP, et al. Self-strengthening hybrid dental adhesive via visible-light irradiation triple polymerization[J]. RSC Adv, 2016, 6(57):52434-52447.
[44] Ciumac D, Gong HN, Hu XZ, et al. Membrane targeting cationic antimicrobial peptides[J]. J Colloid Interface Sci, 2019, 537:163-185.