生物活性玻璃的抗菌机制及其影响因素

doi:10.13591/j.cnki.kqyx.2022.06.013

摘要/Abstract

摘要： 生物活性玻璃(bioactive glasses,BGs)是一种以SiO₂-Na₂O-CaO-P₂O₅氧化物体系为基础的生物活性材料,具有良好的成骨活性、抗菌性和生物相容性。BGs对临床上常见的多种口腔细菌都具有显著的抗菌作用,且不会产生耐药性,有作为口腔抑菌剂的潜在应用前景。然而对于它的抑菌机制尚未见总结性研究,该文回顾了BGs对口腔常见致病菌的抗菌作用及机制,并对其影响因素进行总结。

关键词: 生物活性玻璃, 抗菌机制, 口腔抑菌剂

Abstract: Bioactive glasses(BGs) are bioactive materials based on the SiO₂-Na₂O-CaO-P₂O₅ oxide system. They have good osteogenic activity, antibacterial activity and biocompatibility. BGs have significant antibacterial effects on common oral bacteria in clinic and will not lead to drug resistance. Thus, BGs have application prospects as oral bacteriostatic agents. However, there is no conclusive research on its antibacterial mechanism. This article reviews the antibacterial effects and mechanisms of BGs on common oral pathogens and summarizes its influencing factors.

Key words: bioactive glasses(BGs), antibacterial mechanism, oral bacteriostatic agent

中图分类号:

R783.1

董峻池, 郑慧玲, 卫羽雯, 马骞. 生物活性玻璃的抗菌机制及其影响因素[J]. 口腔医学, 2022, 42(6): 551-556.

DONG Junchi, ZHENG Huiling, WEI Yuwen, MA Qian. Antibacterial mechanism and influencing factors of bioactive glasses[J]. Stomatology, 2022, 42(6): 551-556.

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