神经营养素对牙髓干细胞神经向分化的影响

doi:10.13591/j.cnki.kqyx.2022.09.015

摘要/Abstract

摘要： 牙髓干细胞(dental pulp stem cells, DPSCs)是一类具有高度增殖、多向分化潜能的成体干细胞,其来源丰富,具有提取较为便捷、伦理争议较小的优势。由于DPSCs具有多向分化的潜能,可以在一定条件下诱导成神经向分化,在神经损伤的修复和神经遗传性疾病的治疗等方面应用前景广阔。神经营养素(neurotrophin, NT)是一类能够促进轴突生长、利于神经细胞分化与存活的由神经所支配的组织或细胞产生的蛋白质分子,可以分为神经营养因子(neurotrophic factor, NTFs)家族、胶质细胞源性神经营养因子(glial cell-derived neurotrophic factor, GDNF)家族、白细胞介素-6(interleukin-6,IL-6)细胞因子家族、成纤维细胞生长因子(fibroblast growth factor, FGF)家族等,NT作为促进神经细胞分化的营养因子,也能够促进干细胞神经向分化,其对DPSCs神经向分化有一定的引导作用。该文简要介绍了NT在促进细胞神经向分化方面的作用,就NT对DPSCs神经向分化的影响和应用前景进行概述。

关键词: 牙髓干细胞, 神经营养素, 神经向分化

Abstract: Dental pulp stem cells (DPSCs) are a kind of adult stem cells with high proliferation and multi-directional differentiation potential. They are rich in sources, convenient for extraction and less controversial in ethics. Because of its potential of multi-directional differentiation, it can be induced into neuronal differentiation under certain conditions, and has a broad application prospect in the repair of nerve injury and the treatment of neurogenetic diseases. Neurotrophins (NT) are a kind of protein molecules produced by innervated tissues or cells that can promote axonal growth and facilitate the differentiation and survival of nerve cells. It can be divided into neurotrophic factors (NTFs) family, glial cell line-derived neurotrophic factor (GDNF) family, interleukin-6 (IL-6) cytokine family, fibroblast growth factor (FGF) family and so on. NT, as a nutritional factor in promoting nerve cell differentiation, can also promote stem cell neuronal differentiation. It has a certain guiding effect on the neuronal differentiation of DPSCs in vitro and in vivo. This paper briefly introduces the signal transduction role of NT in promoting neuronal differentiation, and summarizes the effect and application prospect of NT on nerve differentiation of DPSCs.

Key words: dental pulp stem cell, neurotrophin, neuronal differentiation

中图分类号:

R341.8

薛冰, 席花蕾, 姚丽红, 徐婉秋, 许晓航, 王秀梅. 神经营养素对牙髓干细胞神经向分化的影响[J]. 口腔医学, 2022, 42(9): 846-850.

XUE Bing, XI Hualei, YAO Lihong, XU Wanqiu, XU Xiaohang, WANG Xiumei. Effects of neurotrophic factors on neural differentiation of dental pulp stem cells[J]. Stomatology, 2022, 42(9): 846-850.

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