肿瘤相关巨噬细胞在口腔癌中作用的研究进展

摘要/Abstract

摘要： 　肿瘤相关巨噬细胞（tumor associated macrophages, TAMs）是肿瘤微环境中重要的免疫细胞和炎症细胞，在肿瘤的发生、增殖、侵袭和转移中发挥重要作用。该文从口腔癌中TAMs的来源及分化、促口腔癌前病损进展、致口腔癌侵袭转移等方面对TAMs在口腔癌发生发展中的作用进行综述，以期为针对TAMs的口腔癌研究及靶向治疗提供新思路。

关键词: 肿瘤相关巨噬细胞, 口腔癌, 鳞状细胞癌, 肿瘤微环境

Abstract: Tumor associated macrophages (TAMs) are important immune cells and inflammatory cells in tumor microenvironment, and play an important role in the initiation, progression, invasion and metastasis of human cancers. In this essay, the origin, polarization of TAMs and their clinical effect on oral cancer and precancerous lesions are discussed. The role of TAMs in cancer invasion and metastasis is also studied, in order to provide new ideas and strategies for OSCC research and treatment.

Key words: tumor-associated macrophages, oral cancer, squamous cell carcinoma, tumor microenvironment

中图分类号:

Q279

胡永江宏兵吴煜农刘来奎. 肿瘤相关巨噬细胞在口腔癌中作用的研究进展[J]. 口腔医学, 2021, 41(10): 951-956.

参考文献 60

[1]	Torre LA, Bray F, Siegel RL, et al.Global cancer statistics,2012[J].CA Cancer J Clin, 2015, 65(2):87-108
[2]	Chen W, Zheng R, Baade PD, et al.Cancer statistics in China, 2015[J][J]. CA Cancer J Clin, 2016, 66(2):115-132
[3]	Shellenberger TD, Weber RS.Multidisciplinary Team Planning for Patients with Head and Neck Cancer[J].Oral Maxillofac Surg Clin North Am, 2018, 30(4):435-444
[4]	Curry JM, Sprandio J, Cognetti D, et al.Tumor microenvironment in head and neck squamous cell carcinoma[J].Semin Oncol, 2014, 41(2):217-234
[5]	Plzák J, Bou?ek J, Bandúrová V, et al.The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy[J].Cancers(Basel), 2019, 11(4):E440-E440
[6]	Wolf GT, Chepeha DB, Bellile E, et al.Tumor infiltrating lymphocytes (TIL) and prognosis in oral cavity squamous carcinoma: A preliminary study[J].Oral Oncol, 2015, 51(1):90-95
[7]	Chanmee T, Ontong P, Konno K, Itano N.Tumor-associated macrophages as major players in the tumor microenvironment[J].Cancers (Basel), 2014, 6(3):1670-1690
[8]	Liu Y, Cao X.The origin and function of tumor-associated macrophages[J].Cell Mol Immunol, 2015, 12(1):1-4
[9]	Sica A, Mantovani A.Macrophage plasticity and polarization: in vivo veritas[J].J Clin Invest, 2012, 122(3):787-795
[10]	Franklin RA, Liao W, Sarkar A, et al.The cellular and molecular origin of tumor-associated macrophages[J].Science, 2014, 344(6186):921-925
[11]	Wu FL, Nolan K, Strait AA, et al.Macrophages Promote Growth of Squamous Cancer Independent of T cells[J].J Dent Res, 2019, 98(8):896-903
[12]	Liu SY, Chang LC, Pan LF, et al.Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma[J].Oral Oncol, 2008, 44(3):277-285
[13]	Essa AA, Yamazaki M, Maruyama S, et al.Tumour-associated macrophages are recruited and differentiated in the neoplastic stroma of oral squamous cell carcinoma[J].Pathology, 2016, 48(3):219-227
[14]	Mori K, Hiroi M, Shimada J, et al.Infiltration of m2 tumor-associated macrophages in oral squamous cell carcinoma correlates with tumor malignancy [J][J]. Cancers (Basel), 2011, 3(4):3726-3739
[15]	Costa NL, Valadares MC, Souza PP, et al.Tumour associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma[J].Oral Oncol, 2013, 49(3):216-223
[16]	Weber M, Iliopoulos C, Moebius P, et al.Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas[J][J]..Oral Oncol, 2016, 52(1):75-84
[17]	Yamagata Y, Tomioka H, Sakamoto K, et al.CD163-Positive Macrophages Within the Tumor Stroma Are Associated With Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma[J].J Oral Maxillofac Surg, 2017, 75(10):2144-2153
[18]	Haque ASMR, Moriyama M, Kubota K, et al.CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production[J].Sci Rep, 2019, 9(1):14611-14611
[19]	Lu CF, Huang CS, Tjiu JW, et al.Infiltrating macrophage count: a significant predictor for the progression and prognosis of oral squamous cell carcinomas in Taiwan[J].Head Neck, 2010, 32(1):18-25
[20]	Chawla H, Urs AB, Augustine J.Association of Macrophages with Angiogenesis in Oral Epithelial Dysplasia,Oral Verrucous Carcinoma,and Oral Squamous Cell Carcinoma: An Immunohistochemical Study[J].Appl Immunohistochem Mol Morphol, 2017, 25(3):203-208
[21]	Wang S, Sun M, Gu C, et al.Expression of CD163,interleukin-10,and interferon-gamma in oral squamous cell carcinoma: mutual relationships and prognostic implications[J].Eur J Oral Sci, 2014, 122(3):202-220
[22]	Mori K, Haraguchi S, Hiori M, et al.Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment[J][J]. BMC Cancer, 2015, 15:573., 2915, 15(15):573-573
[23]	Petruzzi MN, Cherubini K, Salum FG, et al.Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge[J].Diagn Pathol, 2017, 12(1):32-32
[24]	Kouketsu A, Sato I, Oikawa M, et al.Regulatory T cells and M2-polarized tumour-associated macrophages are associated with the oncogenesis and progression of oral squamous cell carcinoma[J].Int J Oral Maxillofac Surg, 2019, 48(10):1279-1288
[25]	Sun Y, Liu N, Guan X, et al.Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma[J][J]..Mediators Inflamm, 2016, 2016(57):5715719-5715719
[26]	Marcus B, Arenberg D, Lee J, et al.Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma[J].Cancer, 2004, 101(12):2779-2787
[27]	Fujii N, Shomori K, Shiomi T, et al.Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance[J].J Oral Pathol Med, 2012, 41(6):444-451
[28]	Bagul N, Roy S, Ganjre A, et al.Quantitative Assessment of Tumor Associated Macrophages in Head and Neck Squamous Cell Carcinoma Using CD68 Marker: An Immunohistochemical Study[J][J]. J Clin Diagn Res, 2016, 10(4):81-84
[29]	Boas DSV, Takiya CM, Coelho-Sampaio TL, et al.Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma[J].J Oral Pathol Med, 2010, 39(7):565-570
[30]	Ni YH, Ding L, Huang XF et al.Microlocalization of CD68+ tumor-associated macrophages in tumor stroma correlated with poor clinical outcomes in oral squamous cell carcinoma patients[J].Tumour Biol, 2015, 36(7):5291-5298
[31]	Zhang QW, Liu L, Gong CY, et al.Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature[J].PLoS One, 2012, 7(12):e50946-e50946
[32]	Troiano G, Caponio VCA, Adipietro I, et al.Prognostic significance of CD68+ and CD163+ tumor associated macrophages in head and neck squamous cell carcinoma: A systematic review and meta-analysis [J]. [J].Oral Oncol, 2019, 93(93):66-75
[33]	Cheng Z, Zhang D, Gong B, et al.CD163 as a novel target gene of STAT3 is a potential therapeutic target for gastric cancer[J].Oncotarget, 2017, 8(50):87244-87262
[34]	Sami E, Paul BT, Koziol JA, et al.The immunosuppressive microenvironment in BRCA1-IRIS-overexpressing TNBC tumors is induced by bidirectional interaction with tumor-associated macrophages. [J].Cancer Res, 2020, 80(5):1102-1117
[35]	De Palma M, Lewis CE.Cancer: Macrophages limit chemotherapy[J].Nature, 2011, 472(7343):303-304
[36]	Ruffell B, Affara NI, Coussens LM.Differential macrophage programming in the tumor microenvironment[J].Trends Immunol, 2012, 33(3):119-126
[37]	Sakakura K, Takahashi H, Kaira K, et al.Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment[J].Lab Invest, 2016, 96(9):994-1003
[38]	Weber M, Moebius P, Büttner-Herold M, et al.Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas--an immunohistochemical study[J].Br J Cancer, 2015, 113(3):510-519
[39]	Jiang C, Yuan F, Wang J, et al.Oral squamous cell carcinoma suppressed antitumor immunity through induction of PD-L1 expression on tumor-associated macrophages[J].Immunobiology, 2017, 222(4):651-657
[40]	Kubota K, Moriyama M, Furukawa S, et al.CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma[J].Sci Rep, 2017, 7(1):1755-1755
[41]	Toge H, Inagaki T, Kojimoto Y, et al.Angiogenesis in renal cell carcinoma: the role of tumor-associated macrophages[J].Int J Urol, 2009, 16(10):801-807
[42]	El-Rouby DH.Association of macrophages with angiogenesis in oral verrucous and squamous cell carcinomas[J].J Oral Pathol Med, 2010, 39(7):559-564
[43]	Nishio K, Motozawa K, Omagari D, et al.Comparison of MMP2 and MMP9 expression levels between primary and metastatic regions of oral squamous cell carcinoma[J].J Oral Sci, 2016, 58(1):59-65
[44]	Sun H, Miao C, Liu W, et al.TGF-β1TβRIISmad3 signaling pathway promotes VEGF expression in oral squamous cell carcinoma tumor-associated macrophages[J].Biochem Biophys Res Commun, 2018, 497(2):583-590
[45]	Li JJ, Mao XH, Tian T, et al.Role of PFKFB3 and CD163 in Oral Squamous Cell Carcinoma Angiogenesis[J].Curr Med Sci, 2019, 39(3):410-414
[46]	Thiery JP, Acloque H, Huang RY, et al.Epithelial-mesenchymal transitions in development and disease[J].Cell, 2009, 139(5):871-890
[47]	Zhang J, Yao H, Song G, Liao X, Xian Y, Li W.Regulation of epithelial-mesenchymal transition by tumor-associated macrophages in cancer[J].Am J Transl Res, 2015, 7(10):1699-1711
[48]	Lee CH, Liu SY, Chou KC, et al.Tumor-Associated Macrophages Promote Oral CancerProgression Through Activation of the Axl Signaling Pathway[J].Ann Surg Oncol, 2014, 21(3):1031-1037
[49]	Chiu KC, Lee CH, Liu SY, et al.Polarization of tumor-associated macrophages and Gas6Axl signaling in oral squamous cell carcinoma[J].Oral Oncol, 2015, 51(7):683-689
[50]	Hu Y, He MY, Zhu LF, et al.Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma [J]. [J].J Exp Clin Cancer Res, 2016, 35(35):12-12
[51]	Wehrhan F, Büttner-Herold M, Hyckel P, et al.Increased malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes - an immunohistochemical study [J]. [J].BMC Cancer, 2014, 14(14):522-522
[52]	Piril? E, V?yrynen O, Sundquist E, et al.Macrophages modulate migration and invasion of human tongue squamous cell carcinoma[J].PLoS One, 2015, 10(3):e0120895-e0120895
[53]	Zhang S, Yang X, Wang L, et al.Interplay between inflammatory tumor microenvironment and cancer stem cells[J].Oncol Lett, 2018, 16(1):679-686
[54]	Yang J, Liao D, Chen C, et al.Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFRStat3Sox-2 signaling pathway[J].StemCells, 2013, 31(2):248-258
[55]	Okuda H, Kobayashi A, Xia B, et al.Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells[J].Cancer Res, 2012, 72(2):537-547
[56]	He KF, Zhang L, Huang CF, et al.CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma [J].[J]. Biomed Res Int, 2014, 2014(2014):838632-838632
[57]	Li X, Bu W, Meng L, et al.CXCL12CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC[J].Exp Cell Res, 2019, 378(2):131-138
[58]	Tang X, Mo C, Wang Y, et al.Anti-tumour strategies aiming to target tumour-associated macrophages[J].Immunology, 2013, 138(2):93-104
[59]	Feinmesser M, Okon E, Schwartz A, et al.Histologic and immunohistochemical characterization of tumor and inflammatory infiltrates in oral squamous cell carcinomas treated with local multikine immunotherapy: the macrophage at the front line[J].Eur Arch Otorhinolaryngol, 2004, 261(7):359-368
[60]	Yang CY, Lin CK, Lin GJ, et al.Triptolide represses oral cancer cell proliferation,invasion,migration,and angiogenesis in co-inoculation with U937 cells[J].Clin Oral Investig, 2017, 21(1):419-427