腭裂伴发渗出性中耳炎的研究进展

摘要/Abstract

摘要： 腭裂患儿常伴发渗出性中耳炎等中耳疾病，间接影响患儿听力及语音发育，其诊治是唇腭裂综合序列治疗中的重要组成部分。该文回顾近年来相关的文章，从临床流行病学发病特点、发病机理及转归、临床表现、治疗方案等方面对腭裂伴发渗出性中耳炎的研究进展做一综述。

关键词: 腭裂, 传导性听力下降, 咽鼓管, 中耳积液, 渗出性中耳炎

Abstract: Children with cleft palate are often accompanied with otitis media with effusion and other middle ear diseases, which make indirect influence on hearing and speech development of children. The diagnosis and treatment of the diseases is an important part of the treatment of cleft lip and palate. In this article, we reviewed the relative articles in recent years in terms of its clinical epidemiological characteristics, pathogenesis, clinical manifestation, treatment etc， and made a brief summary.

Key words: cleft palate, conductive hearing loss, eustachian tube, middle ear effusion, otitis media with effusion

中图分类号:

R782.22

李光南李盛江宏兵. 腭裂伴发渗出性中耳炎的研究进展[J]. , 2016, 36(3): 269-272.

参考文献

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[25]Flynn T,Lohmander A,Moller C,et al.A longitudinal study of hearing and middle ear status in adolescents with cleft lip and palate[J].Laryngoscope,2013,123(6):1374-1380
[26]Alper CM,Losee JE,Mandel EM,et al.Pre- and post-palatoplasty Eustachian tube function in infants with cleft palate[J].Int J Pediatr Otorhinolaryngol,2012,76(3):388-391
[27]Ahn JH,Kang WS,Kim JH,et al.Clinical manifestation and risk factors of children with cleft palate receiving repeated ventilating tube insertions for treatment of recurrent otitis media with effusion[J].Acta Otolaryngol,2012,132(7):702-707
[28]Kobayashi H,Sakuma T,Yamada N,et al.Clinical outcomes of ventilation tube placement in children with cleft palate[J].Int J Pediatr Otorhinolaryngol,2012,76(5):718-721
[29]Hartzell LD,Dornhoffer JL.Timing of tympanoplasty in children with chronic otitis media with effusion[J].CurrOpinOtolaryngol Head Neck Surg,2010,18(6):550-553
[30]Lee CH,Lee JH,Kim HM.Flexible integration of laser myringotomy and ventilation tube for bilateral Otitis media with effusion: analysis of laser tympanostomy versus ventilation tube[J].PLoS One,2014,9(1):e84966-
[31]Gani B,KinshuckAJ,SharmaR.A review of hearing loss in cleft palate patients[J].Int J Otolaryngol,2012,2012:548698-
[32]Szabo C,Langevin K,Schoem S,et al.Treatment of persistent middle ear effusion in cleft palate patients[J].Int J Pediatr Otorhinolaryngol,2010,74(8):874-877
[33] Harman NL,Bruce IA,Kirkham JJ,et al,The Importance of integration of stakeholder views in core outcome set development: otitis media with effusion in children with cleft palate［J］.PLoS One,2015,10(6):e0129514.
[34]Zheng W,Smith JD,Shi B,et al.The natural history of audiologic and tympanometric findings in patients with an unrepaired cleft palate[J].Cleft Palate Craniofac J,2009,46(1):24-29
[35]Skuladottir H,Sivertsen A,Assmus J,et al.Hearing outcomes in patients with cleft lip/palate[J].Cleft Palate Craniofac J,2015,52(2):e23-31
[36]Sheer FJ,Swarts JD,Ghadiali SN.Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions[J].Cleft Palate Craniofac J,2010,47(6):600-610
[37]Perry JL,KuehnDP,SuttonBP.Morphology of the levator veli palatini muscle using magnetic resonance imaging[J].Cleft Palate Craniofac J,2013,50(1):64-75
[38] Rajion ZA,AlKhatib AR,Netherway DJ,et al,The nasopharynx in infants with cleft lip and palates［J］.Int J Pediatr Otorhinolaryngol,2012,76(2):227-234.
[39]Shprintzen RJ,Croft CB.Abnormalities of the eustachian tube orifice in individuals with cleft palate[J].Int J Pediatr Otorhinolaryngol,1981,3(1):15-23
[40]Kemaloglu YK,Kobayashi T,Nakajima T.Analysis of the craniofacial skeleton in cleft children with otitis media with effusion[J].Int J Pediatr Otorhinolaryngol,1999,47(1):57-69
[41]Chang CW,Yang YW,Fu CY,et al.Differences between children and adults with otitis media with effusion treated with CO(2) laser myringotomy[J].J Chin Med Assoc,2012,75(1):29-35
[42]Yang F,Zhao Y,An P,et al.Longitudinal results of intratympanic injection of budesonide for otitis media with effusion in children over 12 2014s and adults[J].Otol Neurotol,2014,35(4):629-634
[43]Caglar O,Bulbul F,Sennaroglu L.Incidence of otitis media with effusion and longterm clinical findings in children with cleft lip and palate types[J].Kulak Burun Bogaz Ihtis Derg,2013,23(5):268-274
[44]Ahn JH,Kang WS,Kim JH,et al.Critical reassessment of the probability of receiving additional ventilation tube insertion for recurrent otitis media with effusion in children with a cleft palate[J].Acta Otolaryngol,2015,135(5):521-522
[45]Kuo CL,Tsao YH,Cheng HM,et al.Grommets for otitis media with effusion in children with cleft palate:a systematic review[J].Pediatrics,2014,134(5):983-994
[46]Kuo CL,Lien CF,Chu CH,et al.Otitis media with effusion in children with cleft lip and palate:a narrative review[J].Int J Pediatr Otorhinolaryngol,2013,77(9):1403-1409
[47]Reiter R,Brosch S,Wefel H,et al.The submucous cleft palate:diagnosis and therapy[J].Int J Pediatr Otorhinolaryngol,2011,75(1):85-88
[48]Harris L,Cushing SL,Hubbard B,et al.Impact of cleft palate type on the incidence of acquired cholesteatoma[J].Int J Pediatr Otorhinolaryngol,2013,77(5):695-698
[49]Handzic〖DD（-1〗＇〖DD）〗 J,Radic〖DD（-1〗＇〖DD）〗 B,Nevajda B,et al.Characteristics of the hearing loss in unilateral cleft lip and palateinfluence on communication[J].Coll Antropol,2011,35(Suppl 1):155-158
[50]Shiao AS,Guo YC.A comparison assessment of videotelescopy for diagnosis of pediatric otitis media with effusion[J].Int J Pediatr Otorhinolaryngol,2005,69(11):1497-1502
[51]Wimmer E,Toleti B,Berghaus A,et al.Impedance audiometry in infants with a cleft palate:The standard 226Hz probe tone has no predictive value for the middle ear condition[J].Int J Pediatr Otorhinolaryngol,2010,74(6):586-590
[52]Chen YW,Chen KT,Chang PH,et al.Is otitis media with effusion almost always accompanying cleft palate in children?:The experience of 319 Asian patients[J].Laryngoscope,2012,122(1):220-224
[53]Mostafapour A,Davoodi S,Ghareaghaji M.Acoustic emission source location in plates using wavelet analysis and cross time frequency spectrum[J].Ultrasonics,2014,54(8):2055-2062
[54]Muntz HR.An overview of middle ear disease in cleft palate children[J].Facial Plast Surg,1993,9(3):177-180
[55]Flynn T,Lohmander A,Moller C,et al.A longitudinal study of hearing and middle ear status in adolescents with cleft lip and palate[J].Laryngoscope,2013,123(6):1374-1380
[56]Alper CM,Losee JE,Mandel EM,et al.Pre and postpalatoplasty Eustachian tube function in infants with cleft palate[J].Int J Pediatr Otorhinolaryngol,2012,76(3):388-391
[57]Ahn JH,Kang WS,Kim JH,et al.Clinical manifestation and risk factors of children with cleft palate receiving repeated ventilating tube insertions for treatment of recurrent otitis media with effusion[J].Acta Otolaryngol,2012,132(7):702-707
[58]Kobayashi H,Sakuma T,Yamada N,et al.Clinical outcomes of ventilation tube placement in children with cleft palate[J].Int J Pediatr Otorhinolaryngol,2012,76(5):718-721
[59]Hartzell LD,Dornhoffer JL.Timing of tympanoplasty in children with chronic otitis media with effusion[J].Curr Opin Otolaryngol Head Neck Surg,2010,18(6):550-553
[60]Lee CH,Lee JH,Kim HM.Flexible integration of laser myringotomy and ventilation tube for bilateral Otitis media with effusion:analysis of laser tympanostomy versus ventilation tube[J].PLoS One,2014,9(1):e84966-