自体富血小板纤维蛋白用于延迟牙再植1例

›› 2016, Vol. 36 ›› Issue (5): 449-452.

自体富血小板纤维蛋白用于延迟牙再植1例

王伟¹,黄超²,刘艳丽²,赵寅华²,张旻²,陈永进²

1. 陕西西安第四军医大学
2. 第四军医大学

收稿日期:2015-12-23 修回日期:2016-02-15 出版日期:2016-05-28 发布日期:2016-06-01
通讯作者: 王伟 E-mail:flybywind@126.com
基金资助:
MGF在力学刺激促PDLSCs/PRF修复脱位再植牙牙周损伤中的作用及机理研究;咬合力刺激促脱位再植牙牙周微循环重建及其机制研究

Use platelet-rich fibrin as an autologous media for delayed teeth replantation: a cases report

Received:2015-12-23 Revised:2016-02-15 Online:2016-05-28 Published:2016-06-01
Contact: wei wang E-mail:flybywind@126.com

摘要/Abstract

摘要： [摘要] 富血小板纤维蛋白（PRF platelet rich fibrin）是一种立体三维网状结构的第二代血小板浓缩物，它能够调节炎症，促进组织愈合。并且能够缓慢持续释放多种生长因子。大量文献报道PRF可以促进口腔软硬组织的愈合，但尚未将其应用于临床牙再植的治疗中。本文联合自体PRF颗粒对一例撕脱2 h且干燥保存的离体牙进行延迟再植、复位固定及后续牙髓治疗。随访1年，脱位牙恢复良好，达到牙周膜性愈合，没有出现牙根吸收，且牙槽骨高度得到恢复。

关键词: 牙再植, PRF , 撕脱性损伤

Abstract: Abstract：PRF (platelet rich fibrin) is a kind of second generation platelet concentrate with a three dimensional reticular structure which can regulate inflammation, accelerate tissue healing, and release a variety of growth factors slowly and continuously. However, no clinical study has used PRF for the treatment of avulsed tooth. In this study, a delayed and dry-reserved avulsion tooth was replanted with autologous PRF. 12-month follow-up showed that the tooth recovered well, the peridental membrane was healed, no root resorption occurred, and the height of alveolar bone was restored.

Key words: Tooth replantation, PRF, avulsion

中图分类号:

R782.1

王伟黄超刘艳丽赵寅华张旻陈永进. 自体富血小板纤维蛋白用于延迟牙再植1例[J]. , 2016, 36(5): 449-452.

参考文献

[1] Zaleckiene V, Peciuliene V, Brukiene V, et al. Traumatic dental injuries: etiology, prevalence and possible outcomes[J]. Stomatologija,2014,16(1);7-14.
[2] Kumar R V, Shubhashini N. Platelet rich fibrin: a new paradigm in periodontal regeneration[J]. Cell Tissue Bank,2013,14(3);453-463.
[3] Zhao Y H, Zhang M, Liu N X, et al. The combined use of cell sheet fragments of periodontal ligament stem cells and platelet-rich fibrin granules for avulsed tooth reimplantation[J]. Biomaterials,2013,34(22);5506-5520.
[4] Andreasen J O. Effect of extra-alveolar period and storage media upon periodontal and pulpal healing after replantation of mature permanent incisors in monkeys[J]. Int J Oral Surg,1981,10(1);43-53.
[5] Zhang X, Gong Y. Characteristics of avulsed permanent teeth treated at Beijing Stomatological Hospital[J]. Dent Traumatol,2011,27(5);379-384.
[6] 张昕，张词，龚怡. 牙撕脱性损伤延迟再植的根面处理[J]. 北京口腔医学,2011(03);175-177.
[7] Panzarini S R, Gulinelli J L, Poi W R, et al. Treatment of root surface in delayed tooth replantation: a review of literature[J]. Dent Traumatol,2008,24(3);277-282.
[8] Diangelis A J, Andreasen J O, Ebeleseder K A, et al. [International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Hebrew edition][J]. Refuat Hapeh Vehashinayim (1993),2014,31(2);57-68, 90.
[9] Hiremath H, Kulkarni S, Sharma R, et al. Use of platelet-rich fibrin as an autologous biologic rejuvenating media for avulsed teeth - an in vitro study[J]. Dent Traumatol,2014,30(6);442-446.
[10] Johns D A, Shivashankar V Y, Maroli R K, et al. Novel management of avulsed tooth by pulpal and periodontal regeneration[J]. J Endod,2013,39(12);1658-1662.
[11] Kassolis J D, Reynolds M A. Evaluation of the adjunctive benefits of platelet-rich plasma in subantral sinus augmentation[J]. J Craniofac Surg,2005,16(2);280-287.