GDF15对成血管和成骨/破骨作用的影响及机制的研究进展

摘要/Abstract

摘要： 生长分化因子15（growth differentiation factor 15, GDF15）作为转化生长因子- β （transforming growth factor β, TGF-β）超家族中的一员，在人体组织中广泛表达。GDF15可被多种因素（比如缺氧、炎症、射线、急性损伤或癌变）诱导表达，通过SMAD通路和非SMAD通路发挥作用。最新的研究表明，在不同微环境下，GDF15对于血管生成，骨代谢具有不同的调节作用。本文就GDF15在不同生物背景下对成骨/成血管作用的影响及其相关信号通路做一综述。

关键词: 生长分化因子15，血管生成，骨代谢，信号通路

Abstract: GDF-15 (also MIC-1, NAG-1, PLAB, PTGFβ) is a member of the TGF-β superfamily, which is widely distributed in mammalian tissues and has received considerable attention revealing a remarkable multifunctional role in controlling biological events. The progress of bone repair and regeneration is closely associated with angiogenesis. The function of GDF15 on angiogenesis and bone metabolism are diverse, depending on the interaction with their microenvironment, and its signaling pathways remain poorly understood. GDF15 may serve as a therapeutic target for bone regeneration and cancer bone metastases.

Key words: Growth differentiation factor 15, Angiogenesis, Bone metabolism, Signaling pathway

中图分类号:

　R329.29

戈旌郑家伟杨驰王绍义王绍义. GDF15对成血管和成骨/破骨作用的影响及机制的研究进展[J]. , 2016, 36(5): 453-457.

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