骨相关细胞的自噬及其在口腔种植中的作用

摘要/Abstract

摘要： 自噬是指部分胞质和细胞内需降解的细胞器、蛋白质等被溶酶体降解的高度保守的过程。许多实验已证实自噬在维持骨相关细胞的稳态中发挥了重要作用，自噬受体的突变会影响成骨及破骨之间的平衡，自噬水平的改变将影响到骨髓间充质干细胞的分化及骨组织的结构、功能等。口腔种植体与周围骨组织形成良好的“骨结合”,是口腔种植成功的关键。自噬通过调节骨代谢平衡以影响种植体周围骨组织的重建及口腔种植的远期临床效果。本文就骨相关细胞中的自噬及其在骨代谢疾病和口腔种植中的作用作一综述。

关键词: 自噬, 骨髓间充质干细胞, 成骨细胞, 破骨细胞, 骨细胞, 口腔种植

Abstract: Autophagy is a highly conserved cellular process in which organelles, proteins and other cytoplasmic components are delivered to lysosomes for degradation. Recently, there came some studies which had demonstrated that autophagy is essential for bone cell homeostasis. Mutations in autophagy receptors will lead to the imbalance between bone formation and resorption. Altering the state of autophagy may change the differentiation of bone marrow derived mesenchymal stem cells and the construction and function of bone. Moreover, clinical success of dental implantation is critically related to the satisfactory osseointegration in which autophagy plays an important role through influencing the peri-implant bone remodeling and regulating bone homeostasis. This review aims to provide a comprehensive overview of autophagy in bone cells and its role in bone metabolic diseases and dental implantation.

Key words: autophagy, bone marrow derived mesenchymal stem cells, osteoblast, osteoclast, osteocyte, dental implant

中图分类号:

R782.12

王超炜周益王慧明. 骨相关细胞的自噬及其在口腔种植中的作用[J]. , 2016, 36(5): 458-461.

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