EGCG开窗灌洗治疗颌骨牙源性角化囊性瘤的临床疗效

›› 2016, Vol. 36 ›› Issue (9): 817-820.

EGCG开窗灌洗治疗颌骨牙源性角化囊性瘤的临床疗效

杨银辉,袁荣涛,孔丽,王科,贾暮云

青岛大学附属医院

收稿日期:2015-11-05 修回日期:2016-01-03 出版日期:2016-09-28 发布日期:2016-10-06
通讯作者: 杨银辉 E-mail:yyh890617@126.com
基金资助:
青岛市公共领域科技支撑计划项目

Outcome of Marsupialization with Epigallocatechin-3-gallate in Treatment of Keratocystic Odontogenic Tumors

Received:2015-11-05 Revised:2016-01-03 Online:2016-09-28 Published:2016-10-06
Contact: Yin-Hui YANG E-mail:yyh890617@126.com

摘要/Abstract

摘要： 目的　应用EGCG（表没食子儿茶素没食子酸酯，epigallocatechin-3-gallate，EGCG）开窗灌洗治疗颌骨牙源性角化囊性瘤，观察其临床疗效。方法 18例颌骨牙源性角化囊性瘤患者，行局部开窗，并制作引流口保持器，分为2组：8例应用EGCG溶液灌洗囊腔，10例应用生理盐水灌洗囊腔。术后定期复诊，每2个月行曲面体层片及CT检查，观察比较两组囊腔变化情况，囊腔长径小于2cm时行二期手术刮除残余囊壁。结果 EGCG溶液灌洗病例，开窗灌洗6-10月后囊腔即缩小至长径小于2cm，行二期刮除手术。生理盐水灌洗病例，需10-16月囊腔缩小至长径小于2cm，可行二期刮除手术。EGCG灌洗病例的临床疗程较生理盐水灌洗组明显缩短，差异有统计学意义，P＜0.05。结论 EGCG开窗灌洗可明显缩短颌骨牙源性角化囊性瘤的治疗周期。

关键词: 牙源性角化囊性瘤, 开窗灌洗, 表没食子儿茶素没食子酸酯

Abstract: Objective It was to evaluate the outcome of marsupialization with epigallocatechin-3-gallate (EGCG) in treatment of keratocysticodontogenic tumors (KCOT). Methods Eighteen patients with KCOT in jaw were treated with marsupialization. Obturator was used to keep drainage open. Eighteen cases were divided into two groups: the cavity was rinsed by EGCG solution in eightcases and by normal saline (NS) in the other ten ones. Panoramic radiograph and CT were taken every two months follow-up. Volume of the cavity was evaluated and curettage was given as the diameter of the cavity was less than 2centimeters.Results Thediameter of the cavity was less than 2centimeters in six to eight months after marsupialization in the group with EGCG and curettage treatment was given to take off the left cyst wall. It need twelve to sixteen months to take curettage in the group with NS. The duration of marsupialization with EGCG was significantly less than that with NS, P＜0.05. Conclusion Marsupialization with EGCG was an effective method to treat KCOT and could obviously reduce the duration of treatment.

Key words: Keratocystic odontogenic tumors, Marsupialization, Epigallocatechin-3-gallate

中图分类号:

R739.82

杨银辉袁荣涛孔丽王科贾暮云. EGCG开窗灌洗治疗颌骨牙源性角化囊性瘤的临床疗效[J]. , 2016, 36(9): 817-820.

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