关键词: 非综合征型单纯腭裂, 危险因素, 病例对照研究

Abstract: Objective To explore the risk factors of non-syndromic cleft palate, which is helpful for its early prevention. Methods A case-control study was performed to detect the environmental risk exposure of non-syndromic cleft palate cases. Univariate and multiple conditional Logistic regression analysis were used to explore the association between risk factors and the risk of non-syndromic cleft palate. And SPSS 19.0 was applied to do the statistical analysis. Results In total, 63 non-syndromic cleft palate cases and 209 healthy controls were recruited in this study. The results of multivariate analysis indicated that family history (OR=19.808), pregnancy parity (OR=3.876), passive smoking during pregnancy (OR=5.076), alcohol drinking during pregnancy (OR=9.414), infection during pregnancy (OR=12.346) and low education level of father (OR=2.780) were risk factors of non-syndromic cleft palate. Conclusions Family history，pregnancy parity, passive smoking during pregnancy, alcohol drinking during pregnancy, infection during pregnancy and low education level of father may be the main risk factors influencing the occurrence of non-syndromic cleft palate in Jiangsu and its surrounding areas.

Key words: non-syndromic cleft palate, risk factors, case control study