RAGE基因多态性与2型糖尿病伴慢性牙周炎遗传易感性的相关研究

摘要/Abstract

摘要： ［摘要］目的探讨晚期糖基化终产物受体(receptor for advanced glycation end products, RAGE)基因的5个SNP位点在2型糖尿病伴慢性牙周炎、单纯慢性牙周炎、健康对照北方汉族人群中分布的差异，从而研究RAGE基因是否为糖尿病和牙周炎可能的致病易感基因。方法运用飞行时间质谱法检测19例2型糖尿病伴慢性牙周炎患者(DM组),22例单纯慢性牙周炎组(CP组)以及54例健康对照组(H组)全血基因组DNA中5个单核苷酸多态性(single nucleotide polymorphism, SNP)位点。结果 rs17846808、rs1800625、rs184003、rs2070600、rs3134940基因多态性在三组间分布无差异。DM组中的rs3134940 A/A（野生纯合子）基因型人群的龈沟出血指数(sulcus bleeding index，SBI)显著高于(A/G+G/G，杂合子和突变纯合子)基因型人群的SBI。CP组中的rs1800625 (T/C+C/C)和rs3134940 (A/G+G/G，杂合子和突变纯合子)基因型人群缺失牙数显著性增高。结论 RAGE基因并非2型糖尿病以及慢性牙周炎的易感基因。rs3134940 G等位基因可能在2型糖尿病伴慢性牙周炎进展过程中起到一定保护作用。

关键词: 基因多态性, 2型糖尿病, 慢性牙周炎, RAGE

Abstract: [Abstract] Objective: To investigate the differential distributions of five single nucleotide polymorphism (SNP) loci of RAGE gene in type 2 diabetes with chronic periodontitis (DM), chronic periodontitis (CP), and healthy controls among northern Chinese Han people, so as to study whether RAGE gene serves as a susceptible candidate gene for both diabetes and periodontitis. Methods: Utilized a flight-time mass spectrometer method to analyze five SNPs of 19 DM subjects, 22 CP subjects, and 54 healthy subjects. Results: The distributions of rs17846808, rs1800625, rs184003, rs2070600, rs3134940 polymorphisms demonstrated no significance among three groups. In DM group, subjects carrying rs3134940 A/A genotype had higher SBI than those carrying A/G+G/G genotypes. In CP group, subjects carrying rs1800625 (T/C+C/C) and rs3134940 (A/G+G/G) genotypes had significant higher loss of teeth. Conclusion: In the samples of this study, RAGE gene fails to demonstrate its potential to be a candidate gene for type 2 diabetes and chronic periodontitis susceptibilities. rs3134940 G allele may have some protective roles in the progression of type 2 diabetes with chronic periodontitis. On top of that, larger studies need to be included to draw any further conclusions.

Key words: gene polymorphisms, type2 diabetes mellitus, chronic periodontitis, RAGE

中图分类号:

R780.2

俞宁孙尚敏刘博钟慧敏潘亚萍钟鸣. RAGE基因多态性与2型糖尿病伴慢性牙周炎遗传易感性的相关研究[J]. , 2018, 38(1): 33-38.

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