›› 2018, Vol. 38 ›› Issue (4): 364-367.

• 综述 • 上一篇    下一篇

骨膜蛋白在人牙周膜干细胞成纤维表达中的研究进展

赵文华1,叶银婷1,李燕燕1,钱远怡1,李丹阳1,汤春波2   

  1. 1. 南京医科大学口腔疾病研究江苏省重点实验室
    2. 江苏省口腔医院
  • 收稿日期:2017-08-14 修回日期:2017-09-21 出版日期:2018-04-28 发布日期:2018-05-03
  • 通讯作者: 汤春波 E-mail:cbtang@njmu.edu.cn
  • 基金资助:
    国家自然科学基金;江苏高校优势学科建设工程资助项目;南京医科大学2016年大学生创新训练计划项目;江苏省口腔疾病研究重点实验室开放课题基金

Research progress of the role of Periostin in the fibroblast expression of human’s periodontal ligament stem cell

  • Received:2017-08-14 Revised:2017-09-21 Online:2018-04-28 Published:2018-05-03

摘要: 骨膜蛋白(Periostin,POSTN),又名成骨细胞特异性因子2(osteoblast-specific factor 2,OSF-2),在骨膜和牙周膜中被发现,是一种组织完整和成熟必不可少的细胞外基质蛋白,在受恒定机械应力的胶原丰富的纤维结缔组织中表达。目前已有研究表明Periostin对于骨、牙齿和心脏的发育均有重要作用。本文就Periostin对人牙周膜干细胞成纤维表达的初步研究进行综述。

关键词: 骨膜蛋白, 牙周膜, 干细胞, 成纤维

Abstract: Periostin(POSTN), also known as osteoblast-specific factor 2 (OSF-2), is found in periosteum and periodontal ligament. It is a kind of extracellular matrix protein that is tissuely integral and essential during maturation, expressed in collagen-enriched fibrous and connective tissue when under constant mechanical stress. At present, studies have shown that Periostin has huge effect on bones;teeth and heart development. In this paper, preliminary studies of the role Periostin plays in the fibroblast expression of human’s periodontal ligament stem cell were reviewed.

Key words: Periostin, Periodontal ligament, Stem cells, Fibroblast

中图分类号: