›› 2018, Vol. 35 ›› Issue (9): 834-838.

• 综述 • 上一篇    下一篇

支架材料的免疫反应对骨组织再生的影响

李筱媛1,葛少华2   

  1. 1. 山东大学口腔医院
    2. 山东大学口腔医学院
  • 收稿日期:2018-01-09 修回日期:2018-02-18 出版日期:2018-09-28 发布日期:2018-09-14
  • 通讯作者: 葛少华 E-mail:shaohuage@sdu.edu.cn
  • 基金资助:
    bFGF和BMP-2序贯释放对牙周组织再生的影响

Effects of immunoreaction of scaffold on bone tissue regeneration

Xiao-Yuan LI1,   

  • Received:2018-01-09 Revised:2018-02-18 Online:2018-09-28 Published:2018-09-14

摘要: 大多数组织工程方法都试图通过将干细胞与生物相容性材料和生物活性因子结合来改善损伤后的再生效果。骨组织工程的主要组成部分是种子细胞、支架材料和生长因子。将支架材料植入骨组织损伤部位,增强细胞的成骨活性,提高骨组织生长的能力,从而促进骨组织再生。然而,植入材料可能引起宿主的免疫反应,决定着骨组织再生的效果。该文就支架材料引起的组织免疫反应对骨组织再生的影响作一综述。

关键词: 支架材料, 免疫反应, 骨组织再生

Abstract: Most tissue engineering approaches attempt to improve the regenerative effect after injury by combining stem cells with biocompatible materials and bioactive factors. The main components of bone tissue engineering are seeding cells, scaffolds and growth factors. The scaffold material is implanted into the bone tissue injury site, which can enhance the osteogenic ability of cells, improve the ability of bone tissue growth, thus promoting bone tissue regeneration. However, the implanted material may cause the host’s immune response, affect the results of bone tissue regeneration. This review summarizes the effects of scaffold-induced tissue immune response on bone tissue regeneration.

Key words: scaffolds, immune response, bone tissue regeneration

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