›› 2018, Vol. 35 ›› Issue (9): 814-818.

• 临床研究 • 上一篇    下一篇

女性灼口综合征患者焦虑、抑郁程度与免疫水平的相关性研究

谷庆1,吴国英2,徐诗语3,李留炀4,钱棱4   

  1. 1. 南京医科大学附属口腔医院
    2. 南京医科大学附属口腔医院-江苏省口腔医院
    3. 南京医科大学附属口腔医院牙体牙髓粘膜科
    4. 南京医科大学
  • 收稿日期:2018-03-12 修回日期:2018-04-23 出版日期:2018-09-28 发布日期:2018-09-14
  • 通讯作者: 吴国英 E-mail:wuguoying888@163.com

The correlation analysis among anxiety-depression and immunity in female patients with burning mouth syndrome

  • Received:2018-03-12 Revised:2018-04-23 Online:2018-09-28 Published:2018-09-14
  • Contact: wu guoYING E-mail:wuguoying888@163.com

摘要: 目的 调查灼口综合征患者焦虑、抑郁情况,探索焦虑、抑郁程度与免疫水平的相关性。方法 收集31例女性灼口综合征(burning mouth syndrome,BMS)患者,通过显相焦虑量表(Manifest Anxiety Scale,MAS)、汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)以及患者体液免疫和淋巴细胞亚群的检测,分析其焦虑抑郁程度和免疫水平的相关性。结果 焦虑组患者IgE水平低于非焦虑组,辅助性T细胞(CD4+)百分比和CD4+/CD8+比值较对照组降低;抑郁组患者总T淋巴细胞比例低于对照组,自然杀伤细胞(NK细胞)比例高于对照组,差异均有统计学意义(P<0.05)。结论 BMS患者焦虑组与非焦虑组的体液免疫水平、细胞免疫水平存在差异,抑郁组与非抑郁组的细胞免疫水平存在差异。

关键词: 灼口综合征, 焦虑, 抑郁, 免疫

Abstract: Objective To investigate the anxiety and depression of the patients with burning mouth syndrome (BMS), and explore the relationships among anxiety-depression and immunity. Methods 31 female patients with BMS were investigated by Manifest Anxiety Scale (MAS), Hamilton Depression Scale (HAMD),humoral immunity and lymphocyte subpopulation tests. The correlation among anxiety-depression and immunity was analyzed. The data were analyzed by SPSS19.0. Results The level of IgE in the anxiety group was lower than the non-anxiety group.The level of Helper T cells (CD4+) and ratio of CD4+/CD8+were lower than the control group. The level of the total lymphocyte in the depression group was lower than the control group, while the level of the natural killer cells was higher. These differences were significant (P<0.05). Conclusion The levels of cellular immunity and humoral immunity in anxiety group have differences with those in non-anxiety group.The level of cellular immunity in depression group has differences with that in non-depression group.

Key words: burning mouth syndrome, anxiety, depression, immunity

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