牙龈卟啉单胞菌与阿尔茨海默病的相关性研究进展

›› 2018, Vol. 38 ›› Issue (12): 1141-1144.

牙龈卟啉单胞菌与阿尔茨海默病的相关性研究进展

胡苡¹,周薇²,宋忠臣³

1. 上海交通大学医学院附属第九人民医院牙周病科;上海市口腔医学重点实验室/上海市口腔医学研究所，国家口腔疾病临床研究中心
2. 上海交通大学医学院附属第九人民医院；上海市口腔医学研究所
3. 上海交通大学医学院附属第九人民医院

收稿日期:2018-03-26 修回日期:2018-04-21 出版日期:2018-12-28 发布日期:2018-12-17
通讯作者: 宋忠臣 E-mail:szhongchen@sina.com
基金资助:
慢性牙周炎和阿尔茨海默病的相关性研究：淀粉样前体蛋白及代谢物的双向调节作用初探;上海交通大学医工交叉项目;上海高校高峰高原学科建设项目

Research Progress on the relation between Porphyromonas gingivalis and Alzheimer's disease

Received:2018-03-26 Revised:2018-04-21 Online:2018-12-28 Published:2018-12-17

摘要/Abstract

摘要： 牙龈卟啉单胞菌（Porphyromonas gingivalis，P.gingivalis）是一种革兰氏阴性厌氧菌，是牙周病的主要致病菌。由于P.gingivalis具有激活宿主炎症、调节免疫反应的能力，其与全身性疾病，特别是阿尔茨海默病（Alzheimer's disease，AD）的相互关系已成为研究热点。AD是一种常见的引起老年人群痴呆的神经退行性病变，以多种炎症介质参与的炎症反应为关键病理机制。本文就二者可能的相互关联机制作一综述。

关键词: 牙龈卟啉单胞菌, 阿尔茨海默病, 炎症介质

Abstract: Porphyromonas gingivalis is a Gram-negative anaerobe that is the main pathogen of periodontitis. Because of its ability to activate the host inflammatory response and to regulate immune responses, it has been a research hotspot to explore the relationship between P.gingivalis and systemic diseases, especially Alzheimer's disease. AD is a common neurodegenerative disease that causes dementia in the elderly with a variety of inflammatory mediators involved in the inflammatory response as the key pathology. This article reviews their possible interrelated mechanisms.

Key words: Porphyromonas gingivalis, Alzheimer’s disease, inflammatory mediator

中图分类号:

R781.4

胡苡周薇宋忠臣. 牙龈卟啉单胞菌与阿尔茨海默病的相关性研究进展[J]. , 2018, 38(12): 1141-1144.

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