›› 2019, Vol. 39 ›› Issue (9): 831-834.
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周可聪1,孙梦君2,束蓉3
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摘要: 牙周炎是人类口腔的常见病,免疫机制在牙周炎的发生发展中有非常重要的作用。程序性死亡分子1(programmed death 1,PD-1)及其配体是近年发现的参与免疫抑制作用的重要分子,在牙周炎患者的外周血淋巴细胞、牙周膜成纤维细胞、牙龈上皮细胞上均有表达,该文将就PD-1信号途径与牙周炎的相关性作一综述。
关键词: 程序性死亡分子1(PD-1), 牙周炎, 免疫机制
Abstract: Periodontitis is a common oral disease in human. The immune mechanism plays an important role in the development of periodontitis. In recent years, it has been found that programmed death 1 (PD-1) and its ligands are important molecules involved in immunosuppression. It has been demonstrated that the molecules involved in PD-1 signaling can be expressed on peripheral blood lymphocytes, periodontal ligament fibroblasts and gingival epithelial cells in patients with periodontitis. This article is to discuss the correlation between PD1 signaling pathway and periodontitis.
Key words: programmed death 1 (PD-1), periodontitis, immune mechanism
中图分类号:
R781.42
周可聪 孙梦君 束蓉. 程序性死亡分子1信号途径与牙周炎相关性的研究进展[J]. , 2019, 39(9): 831-834.
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