Abstract: Periapical periodontitis of young permanent teeth has always been a difficult problem in clinical treatment. Regenerative endodontics is a new method for the treatment of periapical periodontitis of young permanent teeth in recent years. It can not only sterilize the root canal by irrigation, but also avoid mechanical preparation and guide the apical stem cells into the root canal, so as to promote the development of the root and achieve good clinical effect. Through the analysis and review of the relevant research on regenerative endodontics, this paper provides help for clinical selection of the best treatment.