水化硅酸钙类生物材料在口腔医学领域的研究进展

摘要/Abstract

摘要： 　水化硅酸钙类生物材料（CSH）能够在潮湿和血液污染环境中发生自固化反应。CSH具有优良的生物相容性，能诱导磷灰石的形成，使磷灰石成核再矿化并诱导新矿化组织形成。上述这些理化和生物学特性使CSH在根管倒充、盖髓、根管封闭、牙本质再矿化和牙髓再生等口腔医学领域应用范围越来越广。目前，CSH在牙髓再生、牙本质再矿化以及骨和牙骨质再生愈合中发挥关键作用。未来，新的再生齿科将以CSH的不断演变而不断创新。

关键词: 水化硅酸钙, 三氧化矿物聚合体, 硅酸二钙, 硅酸三钙

Abstract: Calcium silicate hydrate biomaterials (CSH) can cure by themselves in wet and blood polluted environment. CSH has excellent biocompatibility, which can nucleate and remineralize the apatite, and finally can induce the formation of new mineralized tissues. These physicochemical and biological characteristics make CSH more and more widely used in the field of stomatology, such as root canal filling, pulp capping, root canal sealing, dentin remineralization, and pulp regeneration. Currently, CSH plays a key role in pulp regeneration, dentin remineralization, bone and cementum regenerative healing. In the future, new regenerative dentistry will continue to innovate with the continuous evolution of CSH.

Key words: calcium silicate hydrate, mineral trioxide aggregate, dicalcium silicate, tricalcium silicate

中图分类号:

R781.3

张峰顾新华. 水化硅酸钙类生物材料在口腔医学领域的研究进展[J]. 口腔医学, 2020, 40(4): 366-370.

参考文献 36

[1]	Torabinejad M, Chivian N.Clinical applications of mineral trioxide aggregate[J].J Endod, 1999, 25(3):197-205
[2]	Nabeel M, Tawfik HM, Abu-Seida AMA, et al.Sealing ability of Biodentine versus ProRoot mineral trioxide aggregate as root-end filling materials[J].Saudi Dent J, 2019, 31(1):16-22
[3]	Pawar SS, Pujar MA, Makandar SD.Evaluation of the apical sealing ability of bioceramic sealer,AH plus & Epiphany: An in vitro study[J].J Conserv Dent, 2014, 17(6):579-582
[4]	Lee BN, Hong JU, Kim SM, et al.Anti-inflammatory and osteogenic effects of calcium silicate-based root canal sealers[J].J Endod, 2019, 45(1):73-78
[5]	Souza LC, Yadlapati M, Dorn SO, et al.Analysis of radiopacity,pH and cytotoxicity of a new bioceramic material[J].J Appl Oral Sci, 2015, 23(4):383-389
[6]	Yang YW, Yu F, Zhang HC, et al.Physicochemical properties and cytotoxicity of an experimental resin-based pulp capping material containing the quaternary ammonium salt and Portland cement[J].Int Endod J, 2018, 51(1):26-40
[7]	Torabinejad M, Alexander A, Vahdati SA, et al.Effect of residual dental pulp tissue on regeneration of dentin-pulp complex: an in vivo investigation[J].J Endod, 2018, 44(12):1796-1801
[8]	Costa F, Sousa Gomes P, Fernandes MH.Osteogenic and angiogenic response to calcium silicate-based endodontic sealers[J].J Endod, 2016, 42(1):113-119
[9]	Wongwatanasanti N, Jantarat J, Sritanaudomchai H, et al.Effect of bioceramic materials on proliferation and odontoblast differentiation of human stem cells from the apical papilla[J].J Endod, 2018, 44(8):1270-1275
[10]	Wu TT, Xu C, Du R, et al.Effects of silicate-based composite material on the proliferation and mineralization behaviors of human dental pulp cells: An in vitro assessment[J].Dent Mater J, 2018, 37(6):889-896
[11]	Chong BS, Pitt Ford TR, Hudson MB.A prospective clinical study of Mineral Trioxide Aggregate and IRM when used as root-end filling materials in endodontic surgery2003[J].Int Endod J, 2009, 42(5):414-420
[12]	Abusrewil SM, McLean W, Scott JA.The use of Bioceramics as root-end filling materials in periradicular surgery: A literature review[J].Saudi Dent J, 2018, 30(4):273-282
[13]	Gandolfi MG, Prati C.MTA and F-doped MTA cements used as sealers with warm gutta-perchaLong-term study of sealing ability[J].Int Endod J, 2010, 43(10):889-901
[14]	Lv F, Zhu L, Zhang J, et al.Evaluation of the in vitro biocompatibility of a new fast-setting ready-to-use root filling and repair material[J].Int Endod J, 2017, 50(6):540-548
[15]	Camps J, Jeanneau C, El Ayachi I, et al.Bioactivity of a calcium silicate-based endodontic cement (BioRoot RCS): interactions with human periodontal ligament cells in vitro[J].J Endod, 2015, 41(9):1469-1473
[16]	Pace R, Giuliani V, Nieri M, et al.Mineral trioxide aggregate as apical plug in teeth with necrotic pulp and immature apices: a 10-year case series[J].J Endod, 2014, 40(8):1250-1254
[17]	Linsuwanont P, Kulvitit S, Santiwong B.Reinforcement of simulated immature permanent teeth after mineral trioxide aggregate apexification[J].J Endod, 2018, 44(1):163-167
[18]	Chisini LA, Grazioli G, Francia A, et al.Revascularization versus apical barrier technique with mineral trioxide aggregate plug: A systematic review[J].G Ital Endodon, 2018, 32(1):9-16
[19]	St Paul A, Phillips C, Lee JY, et al.Provider perceptions of treatment options for immature permanent teeth[J].J Endod, 2017, 43(6):910-915
[20]	Fang YJ, Wang XH, Zhu JJ, et al.Influence of apical diameter on the outcome of regenerative endodontic treatment in teeth with pulp necrosis: A review[J].J Endod, 2018, 44(3):414-431
[21]	Silujjai J, Linsuwanont P.Treatment outcomes of apexification or revascularization in nonvital immature permanent teeth: A retrospective study[J].J Endod, 2017, 43(2):238-245
[22]	Yadav P, Pruthi PJ, Naval RR, et al.Novel use of platelet-rich fibrin matrix and MTA as an apical barrier in the management of a failed revascularization case[J].Dent Traumatol, 2015, 31(4):328-331
[23]	Horsted-Bindslev P, Lovschall H.Treatment outcome of vital pulp treatment[J].Endod Top, 2002, 2(1):24-34
[24]	Giraud T, Jeanneau C, Rombouts C, et al.Pulp capping materials modulate the balance between inflammation and regeneration[J].Dent Mater, 2019, 35(1):24-35
[25]	Brignardello-Petersen R.Mineral trioxide aggregate May be superior to calcium hydroxide for histologic dentin bridge formation after pulp capping[J].J Am Dent Assoc, 2019, 150(3):e29-
[26]	Petrou MA, Alhamoui FA, Welk A, et al.A randomized clinical trial on the use of medical Portland cement,MTA and calcium hydroxide in indirect pulp treatment[J].Clin Oral Investig, 2014, 18(5):1383-1389
[27]	Youssef Youssef Abdelati N, Hassan Elkalla I, Mohamed Awad S, et al.Histopathological evaluation of periodontium after repairing furcation perforation with MTA and biodentine[J].Pediatr Dent J, 2018, 28(1):33-39
[28]	Alsulaimani RS.Immediate and delayed repair of 2 sizes of furcal perforations in dogs' teeth using mineral trioxide aggregate cement[J].J Endod, 2018, 44(6):1000-1006
[29]	Gandolfi MG, Silvia F, Pashley David H, et al.Calcium silicate coating derived from Portland cement as treatment for hypersensitive dentine[J].J Dent, 2008, 36(8):565-578
[30]	Choung HW, Lee DS, Lee JH, et al.Tertiary dentin formation after indirect pulp capping using protein CPNE7[J].J Dent Res, 2016, 95(8):906-912
[31]	Pires PM, Santos TP, Fonseca-Gon?alves A, et al.Mineral density in carious dentine after treatment with calcium silicates and polyacrylic acid-based cements[J].Int Endod J, 2018, 51(11):1292-1300
[32]	Osorio R, Sauro S, Watson TF, et al.Polyaspartic acid enhances dentine remineralization bonded with a zinc-doped Portland-based resin cement[J].Int Endod J, 2016, 49(9):874-883
[33]	Pratiwi AR, Meidyawati R, Djauharie N.The effect of MTA application on the affected dentine remineralization after partial caries excavation (in vivo)[J]. J Phys: Conf Ser, 2017, 884: 012119.
[34]	Marciano MA, Camilleri J, Lucateli RL, et al.Physical,chemical,and biological properties of white MTA with additions of AlF3[J].Clin Oral Investig, 2019, 23(1):33-41
[35]	Zhang F, Yang XY, Zhuang C, et al.Design and evaluation of multifunctional antibacterial ion-doped β-dicalcium silicate cements favorable for root canal sealing[J].RSC Adv, 2016, 6(24):19707-19715
[36]	Shao H, Sun M, Zhang F, et al.Custom repair of mandibular bone defects with 3D printed bioceramic scaffolds[J].J Dent Res, 2018, 97(1):68-76